4 Results for "

phagosomes

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "phagosomes" in MCE Product Catalog:

Neriifolin
Neriifolin
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Cat. No.: HY-N8441
CAS No.: 466-07-9
Synonyms: 17β-Neriifolin
Category:  

Apocynaceae Cardiacglycosides Cerbera manghas Linn. Plants Disease Research Fields Inflammation/Immunology Steroids

Target:  

Atg8/LC3 Na+/K+ ATPase Apoptosis Beclin1

Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na +, K +-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells [2.
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4A-MPLA ammonium
4A-MPLA ammonium
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Cat. No.: HY-N16021
CAS No.: 2260669-09-6
Category:  

Lipids

Target:  

Toll-like Receptor (TLR) Cdc42-binding kinase Galectin

4A-MPLA ammonium is an orally active TLR4 agonist. 4A-MPLA ammonium induces TLR4 endocytosis dependent on Cdc42 and galectin-3, triggering TRIF-mediated signaling and sustained IFN-β production. 4A-MPLA ammonium promotes lipid droplet formation, upregulates interferon-stimulated genes and type I IFN signaling genes, downregulates lysosome/phagosome function genes, and modulates tolerogenic dendritic cell function. 4A-MPLA ammonium can be used for the research of colitis .
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Protein serine/threonine kinase
Protein serine/threonine kinase
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Cat. No.: HY-P2948
CAS No.: 9026-43-1
Synonyms: Ser/Thr protein kinase
Target:  

Bacterial Fungal Ser/Thr Kinase

Research Areas:  

Infection

Protein serine/threonine kinase (Ser/Thr protein kinase) is a signal transduction molecule. Protein serine/threonine kinase phosphorylates specific residues on target substrates, regulates phosphorylation-dependent signal cascades, modulates cellular processes of mycobacteria, blocks phagosome-lysosome fusion, promotes meiotic maturation of Xenopus laevis (African clawed frog) oocytes, rescues the phenotype of Saccharomyces cerevisiae (budding yeast) CDC5 mutants, and exhibits cell cycle phase-specific kinase activity. Protein serine/threonine kinase maintains a tightly regulated cell cycle expression pattern, and sustains the growth and survival of mycobacteria. Protein serine/threonine kinase can be used in studies related to tuberculosis .
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BODIPY−DOX
BODIPY−DOX
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Cat. No.: HY-D3190
CAS No.: 2173116-67-9
BODIPY-DOX is a conjugate composed of BODIPY and Doxorubicin (HY-15142A), as well as a pH-activated fluorescent probe for M1 macrophages and an apoptosis inducer. BODIPY-DOX undergoes pH-induced hydrazone bond cleavage in acidic M1 macrophage phagosomes, thereby releasing cytotoxic Doxorubicin (Dox) and inhibiting the function of pro-inflammatory M1 macrophages. BODIPY-DOX highly selectively inhibits the production of relevant pro-inflammatory cytokines by mouse and human monocyte-derived M1 macrophages, while exerting minimal effects on M2 or unactivated macrophages. Therefore, BODIPY-DOX enables simultaneous fluorescent tracing, differentiation and elimination of specific macrophage subsets, and exhibits the potential to regulate tissue regeneration in zebrafish models .
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