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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
90 Results for "
plasminogen activator inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (90)
90 Results for "plasminogen activator inhibitor" in MCE Product Catalog:
72
Target:
Research Areas:
Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.
72
Target:
Research Areas:
Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.
72
72 Publications Verification
Cat. No.: HY-B0285B
CAS No.: 17440-83-4
Synonyms: MK-870 hydrochloride dihydrate
Target:
Research Areas:
Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2 ) channel.
50
Target:
Research Areas:
Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology Cancer
Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
17
17 Cited Publications
Synonyms: PAI-039; Tiplasinin
Research Areas:
Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM .
10
10 Cited Publications
Research Areas:
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence .
8
8 Cited Publications
Cat. No.: HY-P2333
CAS No.: 533902-29-3
Target:
Research Areas:
8
8 Cited Publications
Cat. No.: HY-P2333A
Target:
Research Areas:
4
4 Cited Publications
Cat. No.: HY-N1504
CAS No.: 119425-90-0
Category:
Dracaena cochinchinensis (Lour.) S. C. Chen Flavonoids Monophenols Metabolic Disease Phenols Agavaceae Plants Dihydrochalcones Disease Research Fields
Target:
3
Research Areas:
Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis. Tranexamic acid is a PROTAC linker. Tranexamic acid is used to synthesize PROTACs (e.g. LZ-07 (HY-172590)) .
3
3 Cited Publications
Target:
Research Areas:
UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion .
3
3 Cited Publications
Cat. No.: HY-111056A
Target:
Research Areas:
UK122 hydrochloride is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 hydrochloride shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50s > 100 μM). UK122 hydrochloride, a 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion .
3
3 Cited Publications
Cat. No.: HY-P70975
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINA5; Acrosomal Serine Protease inhibitor; Prev. PLANH3; PAI-3; Prev. PCI; plasminogen activator inhibitor III; PROCI; plasminogen activator inhibitor-3; PAI3; plasminogen activator inhibitor 3; Protein C inhibitor; Serpin A5; Serine (Or Cysteine) Pro
Species:
Human
Source:
HEK293
2
Target:
Upamostat (WX-671), a prodrug of WX-UK1, is an orally active serine protease inhibitor. Upamostat inhibits the urokinase-type plasminogen activator (uPA) system, blocking the plasminogen activation process mediated by it, thereby suppressing the invasion, migration and metastasis of tumor cells. Upamostat can be used in the research of metastatic breast cancer and locally advanced pancreatic cancer .
2
2 Cited Publications
Cat. No.: HY-W018723
CAS No.: 2498-50-2
Synonyms: p-Aminobenzamidine dihydrochloride
Target:
Research Areas:
4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor. 4-Aminobenzamidine dihydrochloride acts as an orally active urokinase type plasminogen activator (uPA) inhibitor (Ki=82 μM). 4-Aminobenzamidine dihydrochloride can be used for cardiovascular diseases and anti-tumor study .
2
2 Cited Publications
Cat. No.: HY-P71077
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINE1; Endothelial plasminogen activator inhibitor; Prev. PLANH1; Serpin E1; Prev. PAI1; PAI-1; PAI; Serpin Peptidase inhibitor, Clade E (Nexin, plasminogen activator inhibitor Type 1), Member 1; Serine (Or Cysteine) Proteinase inhibitor, Clade E (Nexi
Species:
Human
Source:
HEK293
1
Research Areas:
Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. .
1
Category:
Cardiovascular Disease Toddalia asiatica (L.) Lam. Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields
Target:
1
1
1 Cited Publications
Target:
Research Areas:
ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
