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positive inotropic effect

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By Targets:	5-HT Receptor (1) Adrenergic Receptor (1) Calcium Channel (2) Dopamine Receptor (2) Histamine Receptor (4) Na+/K+ ATPase (1) Phosphodiesterase (PDE) (1) PKC (1) Reference Standards (2) Sodium Channel (4)
By Research Areas:	Cardiovascular Disease (15) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (5)

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Peptides

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Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1233

Octodrine 2-Amino-6-methylheptane; 1,5-Dimethylhexylamine; 6-Methyl-2-heptylamine	Dopamine Receptor	Others
Octodrine (2-Amino-6-methylheptane) is a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Octodrine is found to increase the pain threshold, cardiac rate (positive chronotropic effect) and myocardial contractility (positive inotropic effect) .

HY-19666

DPI 201-106 1 Publications Verification SDZ 201106	Sodium Channel	Cardiovascular Disease
DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect .

HY-B1233A

Octodrine hydrochloride 2-Amino-6-methylheptane hydrochloride; 1,5-Dimethylhexylamine hydrochloride; 6-Methyl-2-heptylamine hydrochloride	Dopamine Receptor	Neurological Disease
Octodrine (2-Amino-6-methylheptane) is a central nervous activator that increases the uptake of dopamine and noradrenaline. Octodrine is found to increase the pain threshold, cardiac rate (positive chronotropic effect) and myocardial contractility (positive inotropic effect) .

HY-105431

ASI-222	Na+/K+ ATPase	Cardiovascular Disease
ASI-222 is an aminosugar cardiac glycoside. ASI-222 can inhibit Na+/K+ ATPase and show positive inotropic effect. ASI-222 can be used for the research of cardiovascular disease .

HY-P5824

Anthopleurin-C	Sodium Channel	Neurological Disease
Anthopleurin-C (APE 2-1) is a cardiotonic polypeptide that shows a powerful positive inotropic effect .

HY-105269A

Org 30029 hydrochloride	Calcium Channel	Cardiovascular Disease
Org 30029 hydrochloride is a Ca ²⁺ sensitizer with positive inotropic effect. Org 30029 hydrochloride can be used for the research of cardiovascular disease .

HY-136677

Lnd 796	Calcium Channel	Cardiovascular Disease
LND 796 is an aminosteroidal derivative with positive inotropic effects similar to those of digitalis. It exhibits electrophysiological, toxic, and inotropic effects in normal and partially potassium-depolarized ventricular muscles. LND 796 requires higher concentrations than digoxin to induce the same toxic symptoms. It exhibits a concentration-dependent positive inotropic effect on guinea pig papillary muscles in normal potassium solution. In partially potassium-depolarized papillary muscles, LND 796 enhances both components of contraction and increases the amplitude of slow action potentials. The mechanism of positive inotropic action of LND 796 involves enhanced calcium entry in calcium channels and inhibition of sodium-potassium ATPase. Due to its expanded positive inotropic range, LND 796 may have potential application in the treatment of congestive heart failure.

HY-116119

BDF 9148	Sodium Channel	Cardiovascular Disease
BDF 9148 is a sodium-channel activator with antiarrhythmic properties that produces a significant CAMP-independent positive inotropic effect in left ventricular myocardium from failing hearts. BDF 9148 is promising for research of myocardial failure .

HY-117574

SB 207710	5-HT Receptor	Cardiovascular Disease
SB 207710 is a highly selective antagonist of the 5-HT4 receptor that has been shown to effectively block the positive inotropic effect induced by serotonin in human right atrial appendage preparations .

HY-164430

Arpromidine BU-E-50	Histamine Receptor	Cardiovascular Disease
Arpromidine (BU-E-50) is the agonist for histamine H2 receptor and the antagonist for histamine H1 receptor. Arpromidine exhibits positive inotropic effect with less risks in causing arrhythmias. Arpromidine can be used in research of congestive heart failure .

HY-19666R

DPI 201-106 (Standard) SDZ 201106 (Standard)	Sodium Channel Reference Standards	Cardiovascular Disease
DPI 201-106 (Standard) is the analytical standard of DPI 201-106. This product is intended for research and analytical applications. DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect .

HY-19089

DPN-205-734	Phosphodiesterase (PDE)	Cardiovascular Disease
DPN-205-734 is an orally administered cGMP-PDE inhibitor. DPN-205-734 exhibits positive inotropic effects in various animal cardiomyocytes. DPN-205-734 reduces blood pressure and total peripheral resistance in multiple animal models, demonstrating a debulking effect. DPN-205-734 can be used in research on cardiovascular and cerebrovascular diseases such as heart failure .

HY-107567

Carcinine β-Alanylhistamine	Histamine Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Carcinine (β-Alanylhistamine) is a selective and orally active histamine H3 receptor antagonist with a K_i of 0.2939 μM. Carcinine can reduce histamine content. Carcinine exhibits anti-oxidant activity and neuroprotective effects. Carcinine shows positive inotropic effect and can reduce blood sugar and blood lipid levels. Carcinine can be used for the researches of inflammation, neurological, cardiovascular and metabolic disease, such as retinal damage, seizure and diabetes .

HY-107567B

Carcinine dihydrochloride β-Alanylhistamine dihydrochloride	Histamine Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Carcinine (β-Alanylhistamine) dihydrochloride is the dihydrochloride salt of Carcinine (HY-107567). Carcinine is a selective and orally active histamine H3 receptor antagonist with a K_i of 0.2939 μM. Carcinine can reduce histamine content. Carcinine exhibits anti-oxidant activity and neuroprotective effects. Carcinine shows positive inotropic effect and can reduce blood sugar and blood lipid levels. Carcinine can be used for the researches of inflammation, neurological, cardiovascular and metabolic disease, such as retinal damage, seizure and diabetes .

HY-106829A

OPC 8490	Others	Cardiovascular Disease
OPC 8490 is a stimulant. OPC 8490 has a positive inotropic effect. OPC 8490 can be used for research on heart failure .

HY-106500

Pacrinolol HOE 224	Adrenergic Receptor	Cardiovascular Disease
Pacrinolol (HOE 224) is a selective and orally active beta1 adrenergic receptor blocker. Pacrinolol can inhibit Isoprenaline (HY-108353)-induced positive inotropic effect and increased heart rate. Pacrinolol can be used for the research of cardiovascular disease .

HY-165397

NA 0345	PKC	Cardiovascular Disease
NA 0345 is a PKC inhibitor with IC₅₀ values of 70 nM and 110 nM in the presence and absence of 12-O-tetradecanoyl-13-acetate, respectively. NA 0345 inhibits PKC and selectively suppresses the positive inotropic effect mediated by α₁-adrenergic receptors .

HY-107567BR

Carcinine dihydrochloride (Standard) β-Alanylhistamine dihydrochloride (Standard)	Reference Standards Histamine Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Carcinine dihydrochloride (Standard) is the analytical standard of Carcinine (dihydrochloride) (HY-107567B). This product is intended for research and analytical applications. Carcinine (β-Alanylhistamine) dihydrochloride is the dihydrochloride salt of Carcinine (HY-107567). Carcinine is a selective and orally active histamine H3 receptor antagonist with a K_i of 0.2939 μM. Carcinine can reduce histamine content. Carcinine exhibits anti-oxidant activity and neuroprotective effects. Carcinine shows positive inotropic effect and can reduce blood sugar and blood lipid levels. Carcinine can be used for the researches of inflammation, neurological, cardiovascular and metabolic disease, such as retinal damage, seizure and diabetes .

Anthopleurin-C	Sodium Channel	Neurological Disease
Anthopleurin-C (APE 2-1) is a cardiotonic polypeptide that shows a powerful positive inotropic effect .

Octodrine 2-Amino-6-methylheptane; 1,5-Dimethylhexylamine; 6-Methyl-2-heptylamine	Natural Products Classification of Application Fields Ranunculaceae Other Diseases Aconitum carmichaeli Debx. Plants Disease Research Fields Source Classification	Dopamine Receptor
Octodrine (2-Amino-6-methylheptane) is a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Octodrine is found to increase the pain threshold, cardiac rate (positive chronotropic effect) and myocardial contractility (positive inotropic effect) .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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positive inotropic effect

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