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Results for "

rat central nervous system

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (1) Calcium Channel (1) COX (1) Endogenous Metabolite (1) Histamine Receptor (1) iGluR (1) Interleukin Related (1) Leukotriene Receptor (1) Lipoxygenase (1) mAChR (3) Melanocortin Receptor (1) mGluR (4) Monoamine Oxidase (1) nAChR (2) Neurokinin Receptor (1) Neuromedin U Receptor (NMUR) (2) Neuropeptide B/W Receptor (2) Neuropeptide FF Receptor (1) NO Synthase (1) P2X Receptor (1) Phospholipase (1) Potassium Channel (1) Reference Standards (1) Ser/Thr Protease (1) Serotonin Transporter (1) TRP Channel (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (25)

By Targets:

5-HT Receptor (1)

Adrenergic Receptor (1)

Calcium Channel (1)

COX (1)

Endogenous Metabolite (1)

Histamine Receptor (1)

iGluR (1)

Interleukin Related (1)

Leukotriene Receptor (1)

Lipoxygenase (1)

mAChR (3)

Melanocortin Receptor (1)

mGluR (4)

Monoamine Oxidase (1)

nAChR (2)

Neurokinin Receptor (1)

Neuromedin U Receptor (NMUR) (2)

Neuropeptide B/W Receptor (2)

Neuropeptide FF Receptor (1)

NO Synthase (1)

P2X Receptor (1)

Phospholipase (1)

Potassium Channel (1)

Reference Standards (1)

Ser/Thr Protease (1)

Serotonin Transporter (1)

TRP Channel (1)

By Research Areas:

Cancer (1)

Cardiovascular Disease (2)

Endocrinology (1)

Inflammation/Immunology (3)

Metabolic Disease (3)

Neurological Disease (25)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Targets Recommended: Complement System

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1248

Neuropeptide FF NPFF	Neuropeptide FF Receptor	Cardiovascular Disease Neurological Disease
Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, is a NPFF1 and NPFF2 receptors agonist with K_i values of 2.82 nM and 0.21 nM, respectively. Neuropeptide FF induces abstinence syndrome, exerts antiopioid and analgesic effects, releases via calcium-dependent mechanisms from rat spinal cord, regulates memory, autonomic function, and neuroendocrine function, modulates pain and opioid antinociception, reduces food intake, stimulates water intake, alters cardiovascular parameters, and shows differential activity in hypothalamic paraventricular nucleus neurons. Neuropeptide FF is present in mammalian central nervous system and periphery, with NPFF-immunoreactivity increases in rat cerebrospinal fluid during opiate tolerance, and its NPFF gene and NPFF-R2 gene are up-regulated in rat spinal cord and dorsal root ganglia during peripheral inflammation. Neuropeptide FF can be used for the research of opioid tolerance, morphine-induced analgesia, abstinence syndrome, pain, hypertension, nociception, inflammatory pain, and neuropathic pain .

HY-18732

L-NMMA Maximum Cited Publications 11 Publications Verification Tilarginine; Methylarginine	NO Synthase	Neurological Disease Inflammation/Immunology Cancer
L-NMMA (Tilarginine) is a non-selective and competitive inhibitor of nitric oxide synthase. L-NMMA inhibits three subtypes, namely nNOS, eNOS, and iNOS, and reduces NO production . L-NMMA alleviates mechanical allodynia, thermal hyperalgesia, and choroidal fibrosis. L-NMMA is applicable to research related to nociception, bone cancer pain, and myopia .

HY-107648

McN-A-343 2 Publications Verification	mAChR	Neurological Disease Inflammation/Immunology
McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 produces a significant inhibitory effect on Muscarine (HY-121404)-evoked catecholamine secretion from the isolated perfused rat adrenal gland. McN-A-343 is involved in the regulation of neuronal firing and activates enteroendocrine L cells to release glucagon-like peptide 1 (GLP-1) and modulates the secretion of α-melanocyte stimulating hormone (α-MSH) from the pituitary gland in the central nervous system. McN-A-343 reduces colonic inflammation and oxidative stress in Acetic acid (HY-Y0319)-induced ulcerative colitis (UC) mice. McN-A-343 can be used for the study of ulcerative colitis .

HY-NP180

Progesterone/BSA	Calcium Channel	Metabolic Disease
Progesterone/BSA is a conjugate of Progesterone (HY-N0437) and bovine serum albumin (BSA). Progesterone/BSA cannot penetrate the plasma membrane of human sperm, but still rapidly elevates intracellular free calcium and induces the acrosome reaction. Progesterone/BSA can also act as a probe to specifically bind to progesterone-binding proteins on the membrane of rat brain synaptosomes .

HY-110023

Zimelidine dihydrochloride	Serotonin Transporter	Neurological Disease
Zimelidine dihydrochloride is an orally active selective serotonin reuptake inhibitor. Zimelidine dihydrochloride competitively inhibits central 5-HT uptake and desensitizes 5-HT autoreceptors in dorsal raphe nucleus. Zimelidine dihydrochloride time-dependently modulates 5-HT neuronal firing and hippocampal CA3 responses. Zimelidine dihydrochloride strengthens central serotonergic neurotransmission and produces related behavioral changes. Zimelidine dihydrochloride exerts anxiolytic, analgesic, feeding-suppressive and tolerance-attenuating effects. Zimelidine dihydrochloride is used for the study of depressive disorders and analgesic tolerance .

HY-P1238A

Neuromedin U, rat TFA Neuromedin U (rat) TFA; rat neuromedin U-23 TFA	Neuromedin U Receptor (NMUR)	Neurological Disease
Neuromedin U, rat TFA is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.

HY-P3800

[Glp5] Substance P (5-11)	Neurokinin Receptor	Neurological Disease Endocrinology
[Glp5] Substance P (5-11) is an octapeptide. [Glp5] Substance P (5-11) is one of the main substance P fragments in rat central nervous system (CNS). [Glp5] Substance P (5-11) locally modulates dopamine release in rat striatum .

HY-100743

DL-AP4 2-Amino-4-phosphonobutyric acid	mGluR	Neurological Disease Metabolic Disease
DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent K_d of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system .

HY-108960

PPADS	P2X Receptor Interleukin Related	Neurological Disease
PPADS is a P2X receptor (P2X Receptor) antagonist and a reversible competitive antagonist of NAADP receptors, with IC₅₀ values of 68 nM (P2X1) and 214 nM (P2X3), respectively. PPADS alleviates pain-related behaviors in the central and peripheral nervous systems of mice after peripheral neuropathy, inhibits the overproduction of IL-1β, IL-6, iNOS and nNOS, and suppresses the hydrolytic activity of extracellular ATPase. PPADS blocks ATP-mediated inward currents on recombinant rat P2X₁ and P2X₃ receptors, and inhibits purinergic nerve stimulation-induced contraction of rabbit bladder detrusor muscle. PPADS is applicable to research related to neuropathic pain .

HY-137952

NS8593	Potassium Channel TRP Channel	Neurological Disease
NS8593 is an SK channel (small conductance Ca ²⁺-activated K+ channels) inhibitor. NS8593 reversibly inhibited recombinant SK3-mediated currents (human SK3 and rat SK3). NS8593 inhibits all the SK1-3 subtypes Ca ²⁺-dependently (K_d = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca ²⁺). NS8593 does not affect the Ca ²⁺-activated K channels of intermediate and large conductance (hlk and hBK channels, respectively). NS8593 can also inhibit TRPM7 (melastatin-related TRP cation channel 7) (IC₅₀ = 1.6 mM). NS8593 can be used for the study of central nervous system (CNS) related diseases .

HY-101839

ML381 VU0488130	mAChR	Neurological Disease
ML381 (VU0488130) is a highly selective, central nervous system penetrant mAChR M5 orthogonal antagonist (IC₅₀ = 450 nM; Ki = 340 nM). ML381 is unstable in rat plasma and can be mainly used as a molecular probe for in vitro and electrophysiological studies .

HY-P1238

Neuromedin U, rat Neuromedin U (rat); rat neuromedin U-23	Neuromedin U Receptor (NMUR)	Neurological Disease
Neuromedin U, rat is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.

HY-P10289A

Neuropeptide W-30 (rat) acetate NPW30, rat acetate	Neuropeptide B/W Receptor	Neurological Disease
Neuropeptide W-30 (rat) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (rat) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. NPW-30 activates and binds to both GPR7 and GPR8 at similar effective doses .

HY-19648B

Ebiratide TFA HOE-427 TFA	nAChR	Neurological Disease
Ebiratide (HOE-427) TFA is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide TFA enhances acetycholine (ACh) metabolism in rat brain .

HY-120428

VU0410425	mGluR	Neurological Disease
VU0410425 is an mGlu₁ negative allosteric modulator. VU0410425 exhibits potent inhibitory activity for rat mGlu₁ with an IC₅₀ value of 140 nM. VU0410425 can be used for the research of central nervous system disorders .

HY-19648

Ebiratide HOE-427 free base	Melanocortin Receptor nAChR	Neurological Disease
Ebiratide (HOE-427 free base) is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide enhances acetycholine (ACh) metabolism in rat brain .

HY-113802

VUF 8328	Histamine Receptor	Neurological Disease
VUF 8328 is a potent histamine H(3) receptor agonist. VUF 8328 inhibits the electrically-evoked [ ³H]-no-radrenaline release from rat cortical slices. VUF 8328 is promising for research of central nervous system disorders .

HY-P10289

Neuropeptide W-30 (rat) NPW30, rat	Neuropeptide B/W Receptor	Neurological Disease
Neuropeptide W-30 (rat) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (rat) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. NPW-30 activates and binds to both GPR7 and GPR8 at similar effective doses .

HY-100840A

(RS)-4C3HPG 4-Carboxy-3-hydroxyphenylglycine	mGluR	Neurological Disease
(RS)-4C3HPG (4-Carboxy-3-hydroxyphenylglycine) is an effective competitive antagonist at the metabotropic glutamate receptor 1 (mGluR1) in the central nervous system, and it is also an agonist at mGluR2/3. (RS)-4C3HPG exhibits neuroprotective effects in an acute global ischemia rat model .

HY-100743R

DL-AP4 (Standard) 2-Amino-4-phosphonobutyric acid (Standard)	mGluR Reference Standards	Neurological Disease Metabolic Disease
DL-AP4 (Standard) is the analytical standard of DL-AP4. This product is intended for research and analytical applications. DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system .

HY-114873

LY256548 LY25684	Phospholipase COX Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
LY256548 (LY25648) is an orally available anti-ischemic and anti-inflammatory compound with central nervous system activity. LY256548 is an inhibitor of phospholipase A2, 5-lipoxygenase (5-LOX), and COX, and inhibits A23187 (HY-N6687)-stimulated leukotriene B4 production. LY256548 inhibits bone damage and paw swelling in the rat Freund's complete adjuvant-induced arthritis (FCA) model .

HY-116142

CP-283097	iGluR	Neurological Disease
CP-283097 is an orally active and conformationally restricted and NR2B subtype-selective NMDA antagonist. CP-283097 efficiently competitively inhibits the binding of [³H]CP-101,606 to the rat meninges, with an IC₅₀ value of 18 nM. CP-283097 exhibits nearly complete inhibition of the current mediated by the NR2B receptor (IC₅₀ = 206 nM), while the inhibitory effect on the NR2A or NR2C receptors is very weak. CP-283097 demonstrates excellent central nervous system permeability and in vivo efficacy in animal models. CP-283097 can be used for neurological diseases related to excessive activation of NMDA receptors .

HY-136693

L-654284	Adrenergic Receptor	Neurological Disease
L-654284 is an α2-adrenergic receptor antagonist with significant selectivity. L-654284 competes with the binding of 3H-clonidine and 3H-rauwolscine in vitro and shows K_i values of 0.8 nM and 1.1 nM, respectively. L-654284 can block the protrusion effect of clonidine in isolated vas deferens in rats, with a pA2 value of 9.1. L-654284 exhibits remarkable selectivity for α2 and α1 adrenergic receptors, and exhibits a K_i of 110 nM in inhibiting 3H-prazosin binding. L-654284 can significantly increase the turnover rate of norepinephrine in rat cerebral cortex in vivo, showing α2-adrenergic receptor blocking activity in the central nervous system .

HY-181280

VU6083859	Ser/Thr Protease	Neurological Disease
VU6083859 is a blood-brain barrier-permeable TAOK1 inhibitor with an IC₅₀ of 158 nM. VU6083859 selectively inhibits TAOK1, exhibits only weak or no activity against TAOK2 and TAOK3, and shows high selectivity for a variety of other kinases. VU6083859 is applicable to research related to neurodevelopmental disorders and tauopathies.

HY-113203A

Putreanine dihydrochloride	Endogenous Metabolite	Neurological Disease
Putreanine dihydrochloride is an alkaline diamino monocarboxylic acid amino acid that exists exclusively in the central nervous system of mammals and birds. Putreanine dihydrochloride reaches its highest concentration in the caudal region of the brain. Putreanine dihydrochloride appears in the brain tissue of rats 2 weeks after birth, and its concentration gradually increases to adult levels over several months .

HY-123778

VU6007678	mAChR	Neurological Disease
VU6007678 is a CNS-penetrant muscarinic acetylcholine receptor (mAChR) modulator. VU6007678 potentiates acetylcholine-mediated signaling at human M1, M3, M5 and rat M1, M3, M4, M5 muscarinic acetylcholine receptors. VU6007678 is applicable to research related to Alzheimer's disease, schizophrenia, and ischemic stroke .

HY-N18471

5,7-Dihydroxytryptamine 5,7-DHP	Monoamine Oxidase 5-HT Receptor	Cardiovascular Disease Neurological Disease
5,7-Dihydroxytryptamine (5,7-DHP) is an autofluorescent (λ_ex≈365 nm), selective neurotoxin and a transport substrate for MAO-A and 5-HT. 5,7-Dihydroxytryptamine can specifically target and damage central and peripheral 5-HTergic neurons, while affecting 5-HT-related pathways and neurotransmitter balance. 5,7-Dihydroxytryptamine can be used to establish 5-HTergic neuron injury models for studies on neural development, neurodegenerative diseases, as well as mechanisms related to platelet function and retinal neurons .

Progesterone/BSA	Biochemical Assay Reagents
Progesterone/BSA is a conjugate of Progesterone (HY-N0437) and bovine serum albumin (BSA). Progesterone/BSA cannot penetrate the plasma membrane of human sperm, but still rapidly elevates intracellular free calcium and induces the acrosome reaction. Progesterone/BSA can also act as a probe to specifically bind to progesterone-binding proteins on the membrane of rat brain synaptosomes .

Cat. No.	Product Name	Target	Research Area