Search Result
Results for "
sedative
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
2
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-B1316
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Others
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Neurological Disease
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Trimetozine is an orally active sedative. Trimetozine has mild tranquilizing effects. Trimetozine can be used for the research of anxiety .
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- HY-121890
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- HY-119404
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- HY-N8422
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- HY-A0220
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Reserpinine
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Others
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Metabolic Disease
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Rescinnamine is a derivative of the indole alkaloid reserpine. Rescinnamine shows sedative effects. Rescinnamine can be used for hypertension research .
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- HY-U00051
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- HY-B1733
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- HY-17034
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Adrenergic Receptor
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Neurological Disease
Endocrinology
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Medetomidine is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine has sedative and analgesic effects. Medetomidine can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .
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- HY-17034B
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MPV785
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Adrenergic Receptor
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Neurological Disease
Endocrinology
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Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .
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- HY-153584
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GABA Receptor
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Neurological Disease
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MRK-898 is an orally active GABA(A) receptor modulator. MRK-898 binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. However, α1-containing GABA(A) receptors are identified as the "sedative" and α2- and/or α3-containing receptors as the "anxiolytic" subtype(s) .
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- HY-B0781
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Histamine Receptor
mAChR
Adrenergic Receptor
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Neurological Disease
Endocrinology
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Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors .
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- HY-N11706
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(+)-β-Cedrene
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Fungal
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Infection
Inflammation/Immunology
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β-Cedrene ((+)-β-Cedrene) is a sesquiterpene compound that can be isolated from Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibiting antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is also a potent competitive inhibitor of the CYP2B6-mediatedbupropion hydroxylase, with a Ki value of 1.6 μM .
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- HY-12706
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- HY-B1594
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Adalin; Adisomnol; Bromacetocarbamide
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Others
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Neurological Disease
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Carbromal (Adalin; Adisomnol) is a sedative with centrally depressant effects .
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- HY-W050162
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TMCA
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GABA Receptor
5-HT Receptor
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Neurological Disease
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(E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy .
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- HY-119461
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- HY-B0950
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Others
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Neurological Disease
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Mefexamide hydrochloride is a particular psychostimulant that is capable of reversing the psychodepressant effects induced by diazepam and benzodiazepine sedatives .
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- HY-B0950A
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Others
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Neurological Disease
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Mefexamide hydrochloride is a particular psychostimulant that is capable of reversing the psychodepressant effects induced by diazepam and benzodiazepine sedatives .
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- HY-117699
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- HY-116195
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(-)-Linalool
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Others
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Neurological Disease
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L-Linalool, a monoterpene with sedative and anxiolytic potential, has been used in Parkinson's disease research .
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- HY-N8763
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Guaianin A
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Others
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Neurological Disease
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Ciwujianoside E is a triterpene saponin that can be isolated from Acanthopanax senticosus. Ciwujianoside E can be used in study sedative-hypnotic drug .
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- HY-100377
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Anticonvulsant 7903
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Others
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Neurological Disease
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Lvguidingan is a potent anticonvulsant agent. Lvguidingan also has sedative-hypnotic, tranquilizing, and muscle-relaxing actions. Lvguidingan can be used as antiepileptic agent .
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- HY-W181871
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- HY-W008645
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GABA Receptor
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Neurological Disease
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NCS-382 (sodium) is a potent GABA receptor antagonist. NCS-382 (sodium) has anti-sedative and anti-hypnotic activities and can be used in research related to neurological diseases .
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- HY-119832A
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EGIS-2062; EGYT-2062
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Histamine Receptor
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Inflammation/Immunology
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Setastine hydrochloride is an orally effective, non-sedative and long acting anti-allergic agent. Setastine hydrochloride possesses potent histamine Hi-receptor blocking properties and can be used for allergies and rhinitis research [1]<.
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- HY-W740244
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Others
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Metabolic Disease
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4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone. It is an inhibitor of organic anion transporter 3 (OAT3; Ki=16.9 μM) and is selective for OAT3 over OAT1 (Ki=>200 μM).
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- HY-B0163
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- HY-B0163A
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- HY-121118
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- HY-119832
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EGIS-2062 free acid; EGYT-2062 free acid
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Histamine Receptor
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Inflammation/Immunology
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Setastine (EGIS-2062 (free acid); EGYT-2062 (free acid) is an orally effective, non-sedative and long acting anti-allergic agent. Setastine possesses potent histamine Hi-receptor blocking properties and can be used for allergies and rhinitis research [1]<.
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- HY-N8303
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ERK
PAK
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Neurological Disease
Inflammation/Immunology
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Gardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating MAPK/ERK, PKC, and PKA, but not TrkA, CREB signaling pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects .
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- HY-108678
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Oxytocin Receptor
Vasopressin Receptor
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Neurological Disease
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TC OT 39 is a synthetic oxytocin analog, as well as a selective agonist of oxytocin receptor (OXTR, EC50=180 nM). TC OT 39 is also an Avprla vasopressin receptor antagonist with an Ki value of 330 nM. TC OT 39 exhibits sedative effects in mouse models .
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- HY-B1296S1
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- HY-N1919
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Raubasine
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Adrenergic Receptor
Cholinesterase (ChE)
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Neurological Disease
Endocrinology
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Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity .
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- HY-N1919A
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Raubasine hydrochloride
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Adrenergic Receptor
Cholinesterase (ChE)
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Neurological Disease
Endocrinology
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Ajmalicine (Raubasine) hydrochloride is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine hydrochloride is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine hydrochloride also can be used as anti-hypertensive, and serpentine, with sedative activity .
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- HY-160978
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KC-7507 free base
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GABA Receptor
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Neurological Disease
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Timelotem is a representative of a class of 1, 2-cyclo1, 4-benzodiazepines. Timelotem shows significant antipsychotic properties. Timelotem produces sedative, anti-anxiety and anti-convulsant effects by enhancing the action of the neurotransmitter gamma-aminobutyric acid (GABA). Timelotem can be used in studies of schizophrenia and other mental disorders .
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- HY-129105
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GABA Receptor
Cytochrome P450
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Neurological Disease
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Chlormethiazole is an potent and orally active GABAA agonist . Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Chlormethiazole is an anticonvulsant agent and has the potential for treating convulsive status epilepticus .
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- HY-137088
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Others
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Neurological Disease
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Imiclopazine is a phenothiazine derivative with with psychomotor stabilizing properties, antiaggressive and antiemetic effects .
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- HY-A0157
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Dimetotiazine; Fonazine
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Histamine Receptor
5-HT Receptor
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Neurological Disease
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Dimethothiazine (Dimetotiazine; Fonazine) is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine can be used to research hemicrania and spasticity .
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- HY-12394
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Dosulepin; Dothep
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Histamine Receptor
5-HT Receptor
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Neurological Disease
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Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain,idiopathic fibromyalgia syndrome or rheumatoid arthritis .
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- HY-135741
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iGluR
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Neurological Disease
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NYX-2925 is an orally active NMDAR modulator. NYX-2925 restores levels of activated Src and Src phosphorylation sites on GluN2A and GluN2B in the mPFC. NYX-2925 shows no effect on CAMKII, and any addictive or sedative/ataxic side effects. NYX-2925 can be used for research of a variety of NMDA receptor-mediated central nervous system disorders .
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- HY-14658B
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- HY-N2081
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Others
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Inflammation/Immunology
Cancer
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Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity .
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- HY-B1263
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Bacterial
Fungal
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Infection
Neurological Disease
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Chlorobutanol is a pharmaceutical preservative. Chlorobutanol is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol is widely used in food and cosmetic industry .
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- HY-W089856
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Bacterial
Fungal
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Infection
Neurological Disease
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Chlorobutanol hemihydrate is a pharmaceutical preservative. Chlorobutanol hemihydrate is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol hemihydrate is widely used in food and cosmetic industry .
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- HY-N12786
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Others
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Others
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1,3-Dihydroxy-2-methoxyxanthone is a xanthone and can be isolated from Polygala caudata .
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- HY-161539
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Opioid Receptor
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Neurological Disease
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KOR agonist 1 (Compound 7a) is a selective agonist for opioid receptor, with EC50s of 3.4, 701.2 and 1649 nM, for KOR, MOR and DOR, respectively. KOR agonist 1 binds KOR, MOR and DOR, with Kis of 3.9, 1053 and 4196 nM, respectively. KOR agonist 1 exhibits antinociceptive effect in ICR mouse model (ED50 in hot plate test is 0.3 mg/kg, in abdominal constriction test is 0.2 mg/kg) .
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- HY-111283
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(+)-AJ 76; (1S,2R)-AJ 76
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Dopamine Receptor
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Neurological Disease
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AJ-76 ((+)-AJ 76; (1S,2R)-AJ 76) is a dopamine autoreceptor antagonist. AJ-76 can increase the synthesis and turnover of dopamine in the rat brain, while having little effect on the synthesis and turnover of serotonin (5-HT) and norepinephrine. AJ-76 can also antagonize the sedative effects of low-dose apomorphine and has a weak antagonistic effect on postsynaptic dopamine receptor .
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- HY-105542
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Histamine Receptor
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Neurological Disease
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Niaprazine is a histamine H1-receptor antagonist. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research .
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- HY-105542R
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Histamine Receptor
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Neurological Disease
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Niaprazine (Standard) is the analytical standard of Niaprazine. This product is intended for research and analytical applications. Niaprazine is a histamine H1-receptor antagonist. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research .
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- HY-W103463
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1-Phenylpyrrolidin-2-one
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GABA Receptor
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Neurological Disease
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1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a phenyl analogue of GABA with sedative effect, decreasing the exploratory behavior of rats at 50-100 mg/kg (i.v.). 1-Phenyl-2-pyrrolidinone also has been proved to inhibit emotional reactions in dogs and cats. 1-Phenyl-2-pyrrolidinone induces decreases in the pressor reaction to emotional stress without accompanied by normalization of the function of baroreceptor reflexes .
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- HY-B0480
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(±)-Brompheniramine maleate
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Histamine Receptor
mAChR
Potassium Channel
Sodium Channel
Calcium Channel
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Neurological Disease
Inflammation/Immunology
Endocrinology
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Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research .
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- HY-111052
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GABA Receptor
Cytochrome P450
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Neurological Disease
Inflammation/Immunology
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AZD7325 is a potent and orally active partial selective PAM of GABAAα2 and Aα3 receptor (Ki=0.3 and 1.3 nM, respectively), and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes . AZD7325 is a moderate CYP1A2 and a potent CYP3A4 inducer in vitro . AZD7325 has the potential for the investigation of anxiety and dravet syndrome . PAM: positive allosteric modulator.
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- HY-B0480A
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- HY-14264
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5-HT Receptor
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Neurological Disease
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Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity .
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- HY-135895
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- HY-106136
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PD-6735; LY-156735
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Melatonin Receptor
5-HT Receptor
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Neurological Disease
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TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment .
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- HY-160849
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GABA Receptor
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Others
Metabolic Disease
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N-desmethyl Rilmazolam, a triazolobenzodiazepine, serves as an analytical reference standard. N-desmethyl Rilmazolam is an active metabolite derived from rilmazafone (HY-106547). N-desmethyl Rilmazolam is designed for use in research and forensic settings .
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- HY-B0725S
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Histamine Receptor
Cytochrome P450
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Neurological Disease
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Doxepin-d3 (hydrochloride) is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].
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- HY-131997
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GABA Receptor
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Neurological Disease
Inflammation/Immunology
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2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors. 2'MeO6MF also can directly activate α2β2/3 and α2β2/3γ2L GABAA receptors. 2'MeO6MF has anxiolytic and psychomotor stabilizing properties. 2'MeO6MF offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response .
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- HY-105115
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ZK 112119
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GABA Receptor
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Neurological Disease
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Abecarnil (ZK 112119) is a ligand or a partial agonist for benzodiazepine (BZ) receptor. Abecarnil possesses anxiolytic and anticonvulsant properties. Abecarnil can act as a positive allosteric modulator of GABAA receptor. Abecarnil inhibits the binding of the BZ [3H]lormetazepam to rat cerebral cortex membranes, with an IC50 of 0.82 nM. Abecarnil can be used for epilepsy research .
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Cat. No. |
Product Name |
Type |
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- HY-Y1673
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Buffer Reagents
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Potassium bromide, 99% is a salt, widely used as an anticonvulsant and a sedative. Potassium bromide can be used to remove peripheral membrane proteins in molecular biology .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-B0725S
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Doxepin-d3 (hydrochloride) is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].
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- HY-B1296S1
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Promethazine-d4 is a deuterated-labeled promethazine (HY-B0781). Promethazine is an orally active H1 receptor and mAChR antagonist with antihistamine (H1), sedative, antiemetic, anticholinergic, and anti-motion sickness properties .
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