16 Results for "

sputum

" in MedChemExpress (MCE) Product Catalog:
Products (16)

16 Results for "sputum" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-108858
CAS No.: 143831-71-4
Synonyms: rhDNase
Research Areas:  

Inflammation/Immunology

Dornase alfa (rhDNase) is a recombinant human deoxyribonuclease I (rhDNase) that can specifically degrade extracellular DNA. Dornase alfa catalyzes the cleavage of DNA released by neutrophils in respiratory mucus, reduces sputum viscosity, thereby improving mucus clearance efficiency, reducing airway obstruction and alleviating inflammatory responses. Dornase alfa can be used to improve lung function (such as FEV_1) in cystic fibrosis (CF), reduce the risk of acute pulmonary exacerbations, and has good in vivo tolerability. Dornase alfa acts locally on the respiratory tract through aerosol inhalation, specifically improving the high viscosity of mucus caused by DNA accumulation and related respiratory symptoms .
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Cat. No.: HY-B0264
CAS No.: 93-14-1
Synonyms: Guaiacol glyceryl ether; Guaiphenesin; Glycerol guaiacolate
Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough .
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Cat. No.: HY-112624J
CAS No.: 9004-54-0
Synonyms: Dextran 4; Dextran D4; Dextran T4(MW 3200-4800)
Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
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Cat. No.: HY-B0629
CAS No.: 105102-22-5
Research Areas:  

Metabolic Disease Cancer

Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis .
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Cat. No.: HY-B0264R
CAS No.: 93-14-1
Synonyms: Guaiacol glyceryl ether(Standard); Guaiphenesin(Standard); Glycerol guaiacolate (Standard)
Guaifenesin (Standard) is the analytical standard of Guaifenesin. This product is intended for research and analytical applications. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough .
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Cat. No.: HY-159536
CAS No.: 1299417-07-4
Synonyms: KN-002; VR-588
Target:  

JAK

Research Areas:  

Inflammation/Immunology

Frevecitinib (KN-002; VR-588) is a lung-selective pan-JAKs (i.e., JAK1, JAK2, JAK3, TYK2) inhibitor. Frevecitinib reduces sputum eosinophil levels. Frevecitinib reduces fractional exhaled nitric oxide (FeNO) levels. Frevecitinib is used for the research of moderate-to-severe asthma .
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Cat. No.: HY-101276
CAS No.: 459814-89-2
Target:  

MMP

Research Areas:  

Inflammation/Immunology

AZD-1236 is a dual inhibitor of MMP-9 and MMP-12. AZD-1236 selectively inhibits the activities of MMP-9 and MMP-12. AZD-1236 regulates biomarkers, reduces elastin degradation, and decreases lymphocyte levels in sputum and blood. AZD-1236 can be used for research related to chronic obstructive pulmonary disease .
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Cat. No.: HY-119579
CAS No.: 54785-02-3
Adamexina is a derivative of bromhexine (HY-B0372), an expectorant. Adamexina, in addition to retaining the mucolytic effects of reducing sputum viscosity and promoting sputum excretion, also exhibits sympathomimetic and antiviral properties due to the introduction of an adamantyl group .
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Cat. No.: HY-164021
CAS No.: 54340-60-2
Synonyms: BR-222; UR389
Target:  

Drug Derivative

Research Areas:  

Others

Brovanexine hydrochloride (BR-222; UR389) is an expectorant, which reduces the adsorption capacity of sputum and ameliorates lung ventilation function .
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Cat. No.: HY-B0629R
CAS No.: 105102-22-5
Mometasone (Standard) is the analytical standard of Mometasone. This product is intended for research and analytical applications. Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis .
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Cat. No.: HY-P5924
CAS No.: 507238-92-8
Target:  

Bacterial

Research Areas:  

Infection

L-K6L9 shows antimicrobial and antibiofilm activities against P. aeruginosa from cystic fibrosis patients. L-K6L9 is stable and resistant to degradation by cystic fibrosis sputum proteases and will not induce bacterial resistance .
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Cat. No.: HY-P5924A
CAS No.: 426264-61-1
Target:  

Bacterial

Research Areas:  

Infection

D-K6L9 shows antimicrobial and antibiofilm activities against P. aeruginosa from cystic fibrosis patients. D-K6L9 is stable and resistant to degradation by cystic fibrosis sputum proteases and will not induce bacterial resistance .
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Cat. No.: HY-B0264S
CAS No.: 1189924-85-3
Synonyms: Guaiacol glyceryl ether-d3; Guaiphenesin-d3; Glycerol guaiacolate-d3
Guaifenesin-d3 is the deuterium labeled Guaifenesin. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough .
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Cat. No.: HY-D2730
N14G-Fe, the Fe 3+-chelated form of N14G, identifies Mtb in sputum samples with tuberculosis, exhibiting exceptional fluorescence. N14G-Fe can effectively traverse the cell wall and inner membrane region where IrtAB is located .
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Cat. No.: HY-B0264S1
CAS No.: 1329563-41-8
Guaifenesin-d5 is the deuterium labeled Guaifenesin. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough. Guaifenesin also has narcotic effect .
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Cat. No.: HY-172135
Research Areas:  

Inflammation/Immunology

PDE4-IN-26 (Compound A5) is an orally active and highly selective PDE4 inhibitor. PDE4-IN-26 has anti-inflammatory activity and can inhibit the phosphorylation of p38 MAPK. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 can improve pulmonary inflammation, injury and fibrosis, promote sputum secretion and relieve cough in mice. PDE4-IN-26 can be used for the research of lung injury-related diseases .
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