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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
ssDNA binding
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "ssDNA binding" in MCE Product Catalog:
14
Novobiocin (Albamycin; Cathomycin) is an orally active aminocoumarin antibiotic (Antibiotic) and Hsp90 inhibitor. Novobiocin binds to the C-terminal nucleotide-binding site of Hsp90 and inhibits the function of this chaperone; Novobiocin competitively blocks ATP binding to GyrB, targets ParE in N. gonorrhoeae, inhibits human POLθ ATPase and the POLθ helicase-like domain in a non-ATP-competitive manner, and inhibits the catalytic activity of human TOP2A and TOP2B. Novobiocin inhibits MMEJ, blocks the recruitment of POLθ to DNA damage sites, induces ssDNA gap formation and apoptosis (Apoptosis), and exhibits synthetic lethality in HR-deficient tumors. Novobiocin can be used for research on equine piroplasmosis, gonorrhea, HR-deficient tumors, anthrax, melioidosis, and acute promyelocytic leukemia .
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14 Publications Verification
Synonyms: Albamycin sodium; Cathomycin sodium
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1 Cited Publications
Cat. No.: HY-126972A
Purity: 98.02%
RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM) .
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6-Hydroxy-DOPA is a selective and effective allosteric inhibitor of the RAD52 ssDNA binding domain. 6-Hydroxy-DOPA can be used for the research of cancer .
Cat. No.: HY-110286R
CAS No.: 21373-30-8
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6-Hydroxy-DOPA (Standard) is the analytical standard of 6-Hydroxy-DOPA. This product is intended for research and analytical applications. 6-Hydroxy-DOPA is a selective and effective allosteric inhibitor of the RAD52 ssDNA binding domain. 6-Hydroxy-DOPA can be used for the research of cancer .
Cat. No.: HY-169622
CAS No.: 103056-35-5
RAD51-IN-9 (Compound 3a) is a RAD51 inhibitor that can inhibit the binding of RAD51 to ssDNA with an IC50 of 17.85 μM. RAD51-IN-9 has a LD50 against HEK293 cells of 40.21 μM. RAD51-IN-9 can sensitize cells to Mitomycin C (HY-13316) .
Cat. No.: HY-D3082
CAS No.: 2222720-58-1
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Probe L is an AIE-based dual-sensing fluorescent probe for the detection of Zn 2+ and single-stranded DNA (ssDNA). Coordination of Probe L with Zn 2+ restricts intramolecular rotation and triggers ESIPT, turning on fluorescence at 490 nm. Upon further binding of the Probe L-Zn 2+ complex to ssDNA, enhanced emission is generated at 550 nm. Ex/Em = 365/490 nm (Zn 2+); Ex/Em = 365/550 nm (ssDNA) .
Cat. No.: HY-190864
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Research Areas:
FORX-864 is an irreversible covalent inhibitor of RAD52. FORX-864 covalently modifies adjacent cysteines and occupies the ssDNA-binding groove, blocking ssDNA binding. FORX-864 has a target IC50 of 5 nM and 7 nM for human RAD52. FORX-864 inhibits RAD52-dependent single-strand annealing in cells without cytotoxicity and lacks activity in RAD52 knockout cells. FORX-864 can be used for research related to RAD52-mediated diseases .
Cat. No.: HY-P703336
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: RBM38; DJ800J21.2; Prev. RNPC1; Seb4B; HSRNASEB; RNA-binding Region (RNP1, RRM) Containing 1; RNA-binding Region-Containing Protein 1; RNA-binding Motif Protein 38; ssDNA-binding Protein SEB4; CLL-Associated Antigen KW-5; RNA-binding Protein 38; SEB4; RNA
Species:
Human
Source:
E. coli
Cat. No.: HY-P88866
Synonyms: NABP2; OBFC2B; SSB1; SOSS complex subunit B1; Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; Single-stranded DNA-binding protein 1
Cat. No.: HY-P88866A
Synonyms: NABP2; OBFC2B; SSB1; SOSS complex subunit B1; Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; Single-stranded DNA-binding protein 1
Cat. No.: HY-P88557
Synonyms: OBFC2A; SSB2; NABP1; SOSS complex subunit B2; Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; Single-stranded DNA-binding protein 2; SOSS-B2; hSSB2
Cat. No.: HY-P88557A
Synonyms: OBFC2A; SSB2; NABP1; SOSS complex subunit B2; Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; Single-stranded DNA-binding protein 2; SOSS-B2; hSSB2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
