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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
topoII
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "topoII" in MCE Product Catalog:
Cat. No.: HY-151453
CAS No.: 2860554-26-1
Target:
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Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive human DNA topoisomerase II inhibitor with an IC50 value of 3.8 and 10.1 μM for TopoIIα and TopoIIβ, respectively. Topoisomerase IIα-IN-4 shows potent potency in apoptosis induction and cell cycle arrest in HepG2 cells. Topoisomerase IIα-IN-4 exhibits strong antitumor activities against human cancer cell lines, it can be used for the research of cancer .
Cat. No.: HY-172395
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TopoII/tubulin-IN-1 (Compound 1B8) is a TopoII/tubulin inhibitor. TopoII/tubulin-IN-1 can inhibit the proliferation and the level of ROS of tumor cells, induce apoptosis and cell cycle arrest of tumor cells, but has no significant cytotoxicity to normal cells. TopoII/tubulin-IN-1 has antitumor activity .
Cat. No.: HY-148719
CAS No.: 2699768-78-8
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ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor with the IC50 of 7.3 μM. ARN24139 can inhibit cancer cell proliferation and is well tolerated in vivo .
Cat. No.: HY-187098
Research Areas:
TopoII/Tubulin-IN-2 is a Tubulin polymerization inhibitor and a Topoisomerase II activity inhibitor. TopoII/Tubulin-IN-2 induces G2 and M phase arrest of the cell cycle. TopoII/Tubulin-IN-2 promotes cell Apoptosis. TopoII/Tubulin-IN-2 can be used for the research of breast adenocarcinoma and liver cancer .
Cat. No.: HY-187099
Research Areas:
TopoII/Tubulin-IN-3 is a Tubulin and Topoisomerase II inhibitor. TopoII/Tubulin-IN-3 induces G2 and M phase cell cycle arrest and promotes cell Apoptosis. TopoII/Tubulin-IN-3 exhibits anticancer activity against breast adenocarcinoma and liver cancer. TopoII/Tubulin-IN-3 can be used in studies related to breast adenocarcinoma and liver cancer .
Cat. No.: HY-153685
CAS No.: 2097636-49-0
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NISC-6 is a novel dual Topo-IIα/Akt inhibitor. NISC-6 has inhibitory activity against various cells, such as UACC903 (IC50 = 2.5 µM) and CHL-1 (IC50 = 0.8 µM) cells. NISC-6 dose dependently induces early and late apoptosis. NISC-6 can be used for research on melanoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
