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Cat. No.: HY-148719

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ARN24139

Name: ARN24139
Brand: MedChemExpress
SKU: HY-148719
Price: 245.00 USD
Availability: InStock
Rating: 5 (1 reviews)

ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor with the IC₅₀ of 7.3 μM. ARN24139 can inhibit cancer cell proliferation and is well tolerated in vivo.

For research use only. We do not sell to patients.

CAS No.: 2699768-78-8
Formula: C₂₄H₁₆F₃N₃O₄S
Molecular Weight:499.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

ARN24139 Chemical Structure

CAS No.: 2699768-78-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor with the IC₅₀ of 7.3 μM. ARN24139 can inhibit cancer cell proliferation and is well tolerated in vivo^[1].

All Topoisomerase Isoforms :

In Vitro

ARN24139(compound 3f) has antiproliferative activity on DU145, HeLa and A549 cells with the IC₅₀ values of 4.7, 3.8 and 3.1μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The pharmacokinetic parameters of ARN24139(compound 3f) in mice

Parameter	IV (3 mg/kg)	PO (10 mg/kg)
C_max(ng/mL)	7366	428
T_max(min)	5	120
AUC_plasma(min*ng/mL)	295528	77385
t_1/2(min)	30	190
Vd(L/kg)	3	18
CL(L/min/kg)	0.004	-
F(%)	8	8

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2699768-78-8
Molecular Weight 499.46
Formula C₂₄H₁₆F₃N₃O₄S
SMILES

O=C(C1C(N(C(N(C2=CC=CC=C2)C1=O)=S)C3=CC=CC=C3)=O)NC4=CC(OC(F)(F)F)=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jose M Arencibia, et al. Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity. J Med Chem. 2020 Apr 9;63(7):3508-3521. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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