1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. ARN24139

ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor with the IC50 of 7.3 μM. ARN24139 can inhibit cancer cell proliferation and is well tolerated in vivo.

For research use only. We do not sell to patients.

ARN24139 Chemical Structure

ARN24139 Chemical Structure

CAS No. : 2699768-78-8

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Description

ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor with the IC50 of 7.3 μM. ARN24139 can inhibit cancer cell proliferation and is well tolerated in vivo[1].

In Vitro

ARN24139(compound 3f) has antiproliferative activity on DU145, HeLa and A549 cells with the IC50 values of 4.7, 3.8 and 3.1μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The pharmacokinetic parameters of ARN24139(compound 3f) in mice

Parameter IV (3 mg/kg) PO (10 mg/kg)
Cmax(ng/mL) 7366 428
Tmax(min) 5 120
AUCplasma(min*ng/mL) 295528 77385
t1/2(min) 30 190
Vd(L/kg) 3 18
CL(L/min/kg) 0.004 -
F(%) 8 8

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

499.46

Formula

C24H16F3N3O4S

CAS No.
SMILES

O=C(C1C(N(C(N(C2=CC=CC=C2)C1=O)=S)C3=CC=CC=C3)=O)NC4=CC(OC(F)(F)F)=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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ARN24139 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ARN24139
Cat. No.:
HY-148719
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