538 Results for "

transmembrane protein

" in MedChemExpress (MCE) Product Catalog:
Products (538)

538 Results for "transmembrane protein" in MCE Product Catalog:

28
28 Publications Verification
Cat. No.: HY-15206
CAS No.: 10238-21-8
Purity:  99.94%
Synonyms: Glyburide
Glibenclamide (Glyburide) is an orally active ATP-sensitive K + channel (KATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .
loading...
    loading...
20
20 Cited Publications
Cat. No.: HY-12326A
CAS No.: 2734909-87-4
Synonyms: Cyclic diadenylate disodium; Cyclic-di-AMP disodium
c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
loading...
    loading...
20
20 Cited Publications
Cat. No.: HY-12326B
Purity:  99.36%
Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium
c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-145603
CAS No.: 2374124-49-7
Purity:  98.19%
Synonyms: VX-121
Target:  

CFTR Chloride Channel

Research Areas:  

Neurological Disease

Vanzacaftor (VX-121) is an orally active noval corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves processing and trafficking of CFTR protein as well as increases chloride transport in triple combined with Tezacaftor (HY-15448) and Deutivacaftor. Vanzacaftor-Tezacaftor-Deutivacaftor is safe and well tolerated, improving lung function, respiratory symptoms, and CFTR function with cystic fibrosis, which is promising for research in the field of cystic fibrosis diseases .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-P70700A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: STING1; HSTING; Prev. TMEM173; N-Terminal Methionine-Proline-Tyrosine-Serine Plasma Membrane Tetraspanner; transmembrane protein 173; Stimulator Of Interferon Response CGAMP Interactor-DeltaC; STING; Stimulator Of Interferon Response CGAMP Interactor-Delt
Species:  
Human
Source:  
E. coli
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-100612
CAS No.: 552309-42-9
Purity:  ≥99.0%
Target:  

Chloride Channel

Research Areas:  

Others

T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC) .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P75951
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GPNMB; Glycoprotein Nonmetastatic Melanoma protein B; Glycoprotein Nmb; Osteoactivin; HGFIN; Hematopoietic Growth Factor Inducible Neurokinin-1; NMB; transmembrane Glycoprotein HGFIN; Glycoprotein (transmembrane) Nmb; Uncharacterized protein GPNMB; Transm
Species:  
Human
Source:  
HEK293
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P70147
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRP1; transmembrane Receptor; Neuropilin 1; CD304 Antigen; VEGF165R; DKFZp686M1967; NRP; Neuropilin; Neuropilin-1; BDCA4; CD304; NP1; Vascular Endothelial Cell Growth Factor 165 Receptor
Species:  
Human
Source:  
HEK293
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P77116
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GPNMB; Glycoprotein Nonmetastatic Melanoma protein B; Glycoprotein Nmb; Osteoactivin; HGFIN; Hematopoietic Growth Factor Inducible Neurokinin-1; NMB; transmembrane Glycoprotein HGFIN; Glycoprotein (transmembrane) Nmb; Uncharacterized protein GPNMB; Transm
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-N0247
CAS No.: 58558-08-0
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the 5-HT2C receptor with an EC50 of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer activities thus can be studies in research for cancers such as Medulloblastoma (MB) .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P70700
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: STING1; HSTING; Prev. TMEM173; N-Terminal Methionine-Proline-Tyrosine-Serine Plasma Membrane Tetraspanner; transmembrane protein 173; Stimulator Of Interferon Response CGAMP Interactor-DeltaC; STING; Stimulator Of Interferon Response CGAMP Interactor-Delt
Species:  
Human
Source:  
E. coli
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P1925A
CAS No.: 1222186-26-6
Research Areas:  

Cancer

GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P700468
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GLP1R; GLP-1-R; Glucagon Like Peptide 1 Receptor; Seven transmembrane Helix Receptor; Glucagon-Like Peptide 1 Receptor; GLP1 Receptor; GLP-1R; GLP-1; GLP-1 Receptor
Species:  
Human
Source:  
HEK293
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P7151
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL16; CXCLG16; C-X-C Motif Chemokine Ligand 16; Scavenger Receptor For Phosphatidylserine And Oxidized Low Density Lipoprotein; SR-PSOX; Chemokine (C-X-C Motif) Ligand 16; SRPSOX; Small-Inducible Cytokine B16; transmembrane Chemokine CXCL16; CXC Chemokine Ligand 16; C-X-C Motif Chemokine 16; SCYB16
Species:  
Mouse
Source:  
E. coli
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-148033
CAS No.: 52349-26-5
Synonyms: N,N,N-Trimethylchitosan
Trimethyl chitosan (N,N,N-Trimethylchitosan) is a multifunctional polymer and a derivative of Chitosan (HY-B2144A). Trimethyl chitosan targets the absorption enhancing proteins of tight junctions of intestinal and mucosal epithelial cells, induces tight junction protein rearrangement, and increases intercellular permeability. Trimethyl chitosan can stimulate the activity of promoting transmembrane transport of hydrophilic drugs (such as peptides and proteins) and can be used for drug delivery and synthesis of nanoparticles .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-126394
CAS No.: 2204245-48-5
Purity:  99.09%
Synonyms: VX-659
Target:  

CFTR

Research Areas:  

Endocrinology

Bamocaftor (VX-659) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore F508del-CFTR protein function. Bamocaftor can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-109187A
CAS No.: 2095064-06-3
Purity:  99.79%
Synonyms: PTI-801 sodium
Target:  

CFTR

Research Areas:  

Inflammation/Immunology

Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF) .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-109152
CAS No.: 2159103-66-7
Purity:  99.20%
Synonyms: GLPG 3067; ABBV-3067
Target:  

CFTR

Research Areas:  

Others

Navocaftor (GLPG 3067), as a cystic fibrosis transmembrane regulator (CFTR), is a protein modulator (US 20200377491 Al, example 1) .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P70201
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLRT2; Leucine-Rich Repeat transmembrane protein FLRT2; Fibronectin Leucine Rich transmembrane protein 2; KIAA0405; Fibronectin-Like Domain-Containing Leucine-Rich transmembrane protein 2
Species:  
Human
Source:  
HEK293
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P72043
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TMPRSS2; transmembrane Protease, Serine 2; transmembrane Serine Protease 2; Serine Protease 10; PRSS10; Epitheliasin; transmembrane Protease Serine 2
Species:  
Human
Source:  
P. pastoris
loading...
    loading...