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  4. SERTlight

SERTlight is a fluorescent agent that can specifically label serotonergic neuronal cell bodies, dendrites, and axonal projections as fluorescent substrates of the serotonin transporter (SERT). SERTlight is orthogonal to various genetically encoded sensors in terms of optics, pharmacology, and operation, enabling multiple imaging. SERTlight allows the use of GRAB5HT sensors to label distal 5HT axonal projections and simultaneously image the release of endogenous 5HT, providing a new multifunctional molecular tool for studying serotonergic systems.

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SERTlight

SERTlight Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Description

SERTlight is a fluorescent agent that can specifically label serotonergic neuronal cell bodies, dendrites, and axonal projections as fluorescent substrates of the serotonin transporter (SERT). SERTlight is orthogonal to various genetically encoded sensors in terms of optics, pharmacology, and operation, enabling multiple imaging. SERTlight allows the use of GRAB5HT sensors to label distal 5HT axonal projections and simultaneously image the release of endogenous 5HT, providing a new multifunctional molecular tool for studying serotonergic systems[1].

Molecular Weight

336.24

Formula

C13H12F4N2O4
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC(N2)=C(C=C(C2=O)CCN)C=C1F.FC(F)(C(O)=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (297.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9741 mL 14.8703 mL 29.7407 mL
5 mM 0.5948 mL 2.9741 mL 5.9481 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.73%

SDS (251 KB)

COA (250 KB) RP-HPLC (166 KB) LCMS (237 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9741 mL 14.8703 mL 29.7407 mL 74.3517 mL
5 mM 0.5948 mL 2.9741 mL 5.9481 mL 14.8703 mL
10 mM 0.2974 mL 1.4870 mL 2.9741 mL 7.4352 mL
15 mM 0.1983 mL 0.9914 mL 1.9827 mL 4.9568 mL
20 mM 0.1487 mL 0.7435 mL 1.4870 mL 3.7176 mL
25 mM 0.1190 mL 0.5948 mL 1.1896 mL 2.9741 mL
30 mM 0.0991 mL 0.4957 mL 0.9914 mL 2.4784 mL
40 mM 0.0744 mL 0.3718 mL 0.7435 mL 1.8588 mL
50 mM 0.0595 mL 0.2974 mL 0.5948 mL 1.4870 mL
60 mM 0.0496 mL 0.2478 mL 0.4957 mL 1.2392 mL
80 mM 0.0372 mL 0.1859 mL 0.3718 mL 0.9294 mL
100 mM 0.0297 mL 0.1487 mL 0.2974 mL 0.7435 mL
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SERTlight Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SERTlightFluorescent Dyeserotonergic systemsNeuronal cell body labelingdendrite labelingand axonal projection labelingInhibitorinhibitorinhibit

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