PD-135666
PD-135666 is a dipeptide inhibitor of cholecystokinin B (CCK B) receptors, binding to CCK B receptors in mouse cerebral cortex with IC50 of 0.1 nM. Its enantiomer, PD-140548, preferentially binds to CCK A receptors with IC50 of 2.8 nM in rat pancreas. PD-135666 exhibits anxiolytic effects in animal models.
For research use only. We do not sell to patients.
- CAS No.: 134557-41-8
- Formula: C33H39N3O5
- Molecular Weight:557.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 0.1 nM (CCK B Receptor)[1]
Chemical Information
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CAS No. 134557-41-8
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Molecular Weight 557.68
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Formula C33H39N3O5
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SMILES
O=C(C[C@H](CC1=CC=CC=C1)NC([C@](NC(OC2C3CC4CC(CC2C4)C3)=O)(CC5=CNC6=C5C=CC=C6)C)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD-135666 Related Classifications
HY-117839 Related Classifications
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