SILA-123
SILA-123 is a FLT3 inhibitor (FLT3-WT: IC50=2.1 nM; FLT3-ITD: IC50=1.0 nM). SILA-123 inhibits FLT3 phosphorylation and downstream signaling pathways, leading to apoptosis by arresting cell cycle progression at the G0/G1 phase. SILA-123 can be used in the study of acute myeloid leukemia.
For research use only. We do not sell to patients.
- CAS No.: 2911585-37-8
- Formula: C24H25N5O2
- Molecular Weight:415.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Chemical Information
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CAS No. 2911585-37-8
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Molecular Weight 415.49
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Formula C24H25N5O2
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SMILES
CC1=NC2=C(C(N)=NO2)C(C3=CC=C(NC(NC4=CC=C(C(C)(C)C)C=C4)=O)C=C3)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)