SIWA318H
SIWA318H is an adbanvced glycation end product (AGE) specific antibody. SIWA318H selectively binds to advanced glycation end product biomarkers, human FcγRIIIa, and pancreatic cancer cells, and cancer-associated fibroblasts. SIWA318H suppresses tumor growth in mouse PSN1 xenografts. SIWA318H can be used for the research of pancreatic cancer.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human
SIWA318H reacts to human pancreatic cancer PSN1 cells and cancer-associated fibroblasts CAF08 via immunofluorescent staining[1].
SIWA318H (0.1-1000 µg/mL; 2 h) binds specifically to CML-BSA in a concentration-dependent manner, with no binding to unmodified BSA[2].
SIWA318H (10-4-104 µg/mL; 2 h) binds to human FcγRIIIa with an EC50 of 59 µg/mL[2].
SIWA318H (1×10-6-1×100 mg/mL; 6 h) induces concentration-dependent ADCC against PSN1 pancreatic cancer cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Humanized CD34+ NSG mice subcutaneously injected with PSN1 pancreatic cancer tumor cells[1]
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Dosage:20 mg/kg (initial dose), followed by 10 mg/kg (subsequent doses); 10 mg/kg (initial dose), followed by 5 mg/kg (subsequent doses)
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Administration:twice weekly; 3 weeks
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Result:Suppressed tumor growth by 68.8%.
Achieved a 60% complete remission rate.
Suppressed tumor growth by 61.5%.
Achieved a 77.8% complete remission rate.
Showed no significant antibody treatment-related weight loss.
Advanced glycation end
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SIWA318H Related Classifications
Cat. No.: HY-P992465
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- SIWA318H
- Fc Receptor (FcR)
- humanized CD34+ NSG mice
- human FcγRIIIa
- antibody-dependent cell-mediated cytotoxicity
- pancreatic cancer cells
- carboxymethyl lysine
- cancer-associated fibroblasts
- patient-derived tumor xenografts
- CAF08
- advanced glycation end product biomarkers
- human pancreatic cancer PSN1 cells
- Inhibitor
- inhibitor
- inhibit