SMU-V18
SMU-V18 is a vesicular stomatitis virus (VSV) inhibitor, with an EC50 of 6.2 μM. SMU-V18 inhibits VSV-GFP fluorescence intensity, viral mRNA/protein expression, and progeny virus replication. SMU-V18 interferes with early viral infection stages, also effective against wild-type VSV (VSV-WT). SMU-V18 inhibits VSV-GFP in mouse tissues and prolongs survival. SMU-V18 can be used for the study of vesicular stomatitis virus (VSV) infection.
For research use only. We do not sell to patients.
- Formula: C19H12F3N3O3
- Molecular Weight:387.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SMU-V18 (1.2-40 μM, 24 h) significantly inhibits VSV-GFP replication (EC50 = 6.2 μM) in HeLa cells, reduces GFP fluorescence intensity, VSV-P mRNA, and GFP expression[1].
SMU-V18 (5-20 μM, 24 h) effectively suppresses progeny VSV-GFP release[1].
SMU-V18 (5-20 μM, 6-24 h) significantly inhibits VSV-WT replication in Vero cells and reduces VSV-WT plaque formation and decreases viral mRNA levels under different MOIs and incubation times[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:5, 10, 20, 40 μM
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Incubation Time:6, 12, 24 h
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Result:Reduced the VSV-P mRNA levels.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:VSV-GFP (5×107 PFU) was intraperitoneally injected into 6-week-old male BALB/c mice to establish a VSV infection animal model[1]
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Dosage:25 mg/kg, 50 mg/kg
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Administration:i.p., once daily, 5 days
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Result:Achieved significant inhibition of VSV-GFP replication in multiple tissues (intestine, liver, kidney, brain) of infected mice.
Showed no severe weight loss (body weight decreased initially then gradually recovered) and significantly improved survival rate.
Reduced VSV-induced splenomegaly, with a significant decrease in the spleen index.
Appeared reduced progeny VSV replication in mouse serum.
Showed alleviation of VSV-GFP-induced pathological damage in multiple organs (heart, lung, intestine), restoring myocardial fiber order, improving alveolar structure, and maintaining intestinal villus integrity .
Chemical Information
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Molecular Weight 387.31
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Formula C19H12F3N3O3
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SMILES
O=C(C1=NC(C2=CC=C3OCCOC3=C2)=NC=C1)NC4=CC(F)=C(F)C(F)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SMU-V18 Related Classifications
HY-175769 Related Classifications
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