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Cat. No.: HY-123524

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STAT3-IN-4

STAT3-IN-4 (compound B9) is a STAT3 inhibitor with K_d values for STAT3 (I634S/Q635G) and WT are 22.75 and 4.59 μM, respectively. STAT3-IN-4 can inhibit the proliferation of tumor cells.

For research use only. We do not sell to patients.

CAS No.: 825611-06-1
Formula: C₂₀H₁₃NO₅S
Molecular Weight:379.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

STAT3-IN-4 Chemical Structure

CAS No.: 825611-06-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

STAT3-IN-4 (compound B9) is a STAT3 inhibitor with K_d values for STAT3 (I634S/Q635G) and WT are 22.75 and 4.59 μM, respectively. STAT3-IN-4 can inhibit the proliferation of tumor cells^[1].

All STAT Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	63.77 μM Compound: B9	Antiproliferative activity against human DU-145 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay Antiproliferative activity against human DU-145 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay	[PMID: 27727126]
MCF7	IC₅₀	133.7 μM Compound: B9	Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay	[PMID: 27727126]
MDA-MB-231	IC₅₀	13.8 μM Compound: B9	Antiproliferative activity against human MDA-MB-231 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay	[PMID: 27727126]
MDA-MB-468	IC₅₀	5.1 μM Compound: B9	Antiproliferative activity against human MDA-MB-468 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-468 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay	[PMID: 27727126]

Chemical Information

CAS No. 825611-06-1
Molecular Weight 379.39
Formula C₂₀H₁₃NO₅S
SMILES

O=S(C1=CC=C(C(C2=C3C=CC=C2)=O)C(C3=O)=C1)(NC4=CC=C(C=C4)O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang M, et al. Screening and biological evaluation of a novel STAT3 signaling pathway inhibitor against cancer. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5172-5176. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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STAT3-IN-4

All STAT Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

STAT3-IN-4 Related Classifications

HY-123524 Related Classifications