STAT3-IN-4
STAT3-IN-4 (compound B9) is a STAT3 inhibitor with Kd values for STAT3 (I634S/Q635G) and WT are 22.75 and 4.59 μM, respectively. STAT3-IN-4 can inhibit the proliferation of tumor cells.
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- CAS No.: 825611-06-1
- Formule: C20H13NO5S
- Masse moléculaire:379.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
63.77 μM
Compound: B9
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Antiproliferative activity against human DU-145 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human DU-145 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
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[PMID: 27727126] |
| MCF7 | IC50 |
133.7 μM
Compound: B9
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
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[PMID: 27727126] |
| MDA-MB-231 | IC50 |
13.8 μM
Compound: B9
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Antiproliferative activity against human MDA-MB-231 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-231 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
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[PMID: 27727126] |
| MDA-MB-468 | IC50 |
5.1 μM
Compound: B9
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Antiproliferative activity against human MDA-MB-468 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-468 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
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[PMID: 27727126] |
Chemical Information
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CAS No. 825611-06-1
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Masse moléculaire 379.39
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Formule C20H13NO5S
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SMILES
O=S(C1=CC=C(C(C2=C3C=CC=C2)=O)C(C3=O)=C1)(NC4=CC=C(C=C4)O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
STAT3-IN-4 Related Classifications
HY-123524 Related Classifications
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