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Cat. No.: HY-P12404

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STR-KALA peptide

STR-KALA peptide is a stearoylated KALA peptide that can be modified on the surface of lipid envelopes. STR-KALA peptide induces pH-independent and acidic pH-dependent membrane destabilization/fusion on endosomal membranes, plasma membranes, and nuclear membranes, mediating endosomal escape and cytosolic delivery of plasmid DNA and encapsulated antigens. STR-KALA peptide can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 1316848-68-6
Formula: C₁₅₁H₂₆₆N₃₈O₃₀
Molecular Weight:3093.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (290 KB)

STR-KALA peptide Chemical Structure

CAS No.: 1316848-68-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

STR-KALA peptide-modified endosomal fusogenic lipid nanoparticles activate dendritic cells and induce cytokines, chemokines, and costimulatory molecules through Toll-like receptor-independent cytosolic DNA sensing involving the STING/TANK-binding kinase and inflammasome pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Plasmid construction

Chemical Information

CAS No. 1316848-68-6
Molecular Weight 3093.96
Formula C₁₅₁H₂₆₆N₃₈O₃₀
SMILES

O=C(N[C@@H](CC1=CNC2=CC=CC=C21)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCCCCCCCCCCCCCCC
Sequence

Stearyl-Trp-Glu-Ala-Lys-Leu-Ala-Lys-Ala-Leu-Ala-Lys-Ala-Leu-Ala-Lys-His-Leu-Ala-Lys-Ala-Leu-Ala-Lys-Ala-Leu-Lys-Ala-NH2
Sequence Shortening

Stearyl-WEAKLAKALAKALAKHLAKALAKALKA-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (290 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Miura N, et al. A KALA-modified lipid nanoparticle containing CpG-free plasmid DNA as a potential DNA vaccine carrier for antigen presentation and as an immune-stimulative adjuvant. Nucleic acids research. 2015 Feb 18;43(3):1317-31.

[2]. Shaheen SM, et al. KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine. Biomaterials. 2011 Sep;32(26):6342-50.

[3]. Miura N, et al. Modifying Antigen-Encapsulating Liposomes with KALA Facilitates MHC Class I Antigen Presentation and Enhances Anti-tumor Effects. Mol Ther. 2017 Apr 5;25(4):1003-1013.

[4]. Tateshita N, et al. Development of a lipoplex-type mRNA carrier composed of an ionizable lipid with a vitamin E scaffold and the KALA peptide for use as an ex vivo dendritic cell-based cancer vaccine. Journal of controlled release : official journal of the Controlled Release Society. 2019 Sep 28;310:36-46.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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