Tallimustine hydrochloride
Based on 1 Customer Validation
Tallimustine hydrochloride, a distamycin-A derivative, is an anticancer agent.
For research use only. We do not sell to patients.
- Purity: 98.23%
- CAS No.: 118438-45-2
- Formula: C32H39Cl3N10O4
- Molecular Weight:734.08
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
0.05 μg/mL
Compound: 1 (Tallimustine)
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In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug)
In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug)
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10.1016/0960-894X(96)00205-3 |
| L1210 | IC50 |
0.42 nM
Compound: tallimustine
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Inhibition of growth in L1210 leukemia cells resistant to doxorubicin(DX).
Inhibition of growth in L1210 leukemia cells resistant to doxorubicin(DX).
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[PMID: 10893305] |
| L1210 | IC50 |
1.2 nM
Compound: tallimustine
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Inhibition of growth in L1210 leukemia cells resistant to Tallimustine.
Inhibition of growth in L1210 leukemia cells resistant to Tallimustine.
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[PMID: 10893305] |
| L1210 | IC50 |
24.4 ng/mL
Compound: 7a (FCE 24517, Tallimustine)
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The activity in vitro on L1210 murine leukemia cells, activity expressed as IC50
The activity in vitro on L1210 murine leukemia cells, activity expressed as IC50
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10.1016/S0960-894X(01)80515-1 |
| L1210 | IC50 |
50.3 ng/mL
Compound: 1a
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In vitro test for cytotoxicity after 48 hr of continuous exposure against L1210 murine leukemia cells
In vitro test for cytotoxicity after 48 hr of continuous exposure against L1210 murine leukemia cells
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10.1016/S0960-894X(97)10120-2 |
| L1210 | IC50 |
50.3 ng/mL
Compound: 4 (Tallimustine)
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In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug)
In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug)
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10.1016/0960-894X(96)00204-1 |
| L1210 | IC50 |
68.5 nM
Compound: 1 (Tallimustine)
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In vitro cytotoxicity against L1210 murine leukemia cells
In vitro cytotoxicity against L1210 murine leukemia cells
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[PMID: 10937717] |
| L1210 | IC50 |
68.5 nM
Compound: tallimustine
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In vitro antitumor activity evaluated against L1210 murine leukemia cell line
In vitro antitumor activity evaluated against L1210 murine leukemia cell line
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[PMID: 10893305] |
Chemical Information
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CAS No. 118438-45-2
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Appearance Solid
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Molecular Weight 734.08
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Formula C32H39Cl3N10O4
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Color Light yellow to light brown
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SMILES
O=C(C1=CC=C(N(CCCl)CCCl)C=C1)NC2=CN(C)C(C(NC3=CN(C)C(C(NC4=CN(C)C(C(NCCC(N)=N)=O)=C4)=O)=C3)=O)=C2.Cl
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Synonyms
FCE 24517 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 83.33 mg/mL (113.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3622 mL | 6.8112 mL | 13.6225 mL | 34.0562 mL |
| 5 mM | 0.2724 mL | 1.3622 mL | 2.7245 mL | 6.8112 mL | |
| 10 mM | 0.1362 mL | 0.6811 mL | 1.3622 mL | 3.4056 mL | |
| 15 mM | 0.0908 mL | 0.4541 mL | 0.9082 mL | 2.2704 mL | |
| 20 mM | 0.0681 mL | 0.3406 mL | 0.6811 mL | 1.7028 mL | |
| 25 mM | 0.0545 mL | 0.2724 mL | 0.5449 mL | 1.3622 mL | |
| 30 mM | 0.0454 mL | 0.2270 mL | 0.4541 mL | 1.1352 mL | |
| 40 mM | 0.0341 mL | 0.1703 mL | 0.3406 mL | 0.8514 mL | |
| 50 mM | 0.0272 mL | 0.1362 mL | 0.2724 mL | 0.6811 mL | |
| 60 mM | 0.0227 mL | 0.1135 mL | 0.2270 mL | 0.5676 mL | |
| 80 mM | 0.0170 mL | 0.0851 mL | 0.1703 mL | 0.4257 mL | |
| 100 mM | 0.0136 mL | 0.0681 mL | 0.1362 mL | 0.3406 mL |
Tallimustine hydrochloride Related Classifications
HY-105270A Related Classifications
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