Tercatain
Tercatain is a COVID-19 main protease inhibitor with antibacterial activity. Tercatain exhibits antibacterial activity against Ralstonia solanacearum. Tercatain can be used for the research of COVID-19, and bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 103744-87-2
- Formula: C34H26O22
- Molecular Weight:786.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Tercatain (7.8-250 μg/mL; 18-36 h) inhibits the growth of Ralstonia solanacearum with an MIC of 52.1 μg/mL[2].
Tercatain potently binds to the catalytic dyad residues (Cys145 and His41) of SARS-CoV-2 3CLpro, qualifying as a potential natural inhibitor of the viral protease[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 103744-87-2
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Molecular Weight 786.56
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Formula C34H26O22
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SMILES
O[C@H]1[C@H](OC(C2=CC(O)=C(O)C(O)=C2)=O)O[C@H](COC(C3=CC(O)=C(O)C(O)=C3C4=C(O)C(O)=C(O)C=C45)=O)[C@@H](OC(C6=CC(O)=C(O)C(O)=C6)=O)[C@@H]1OC5=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Bacterial live/dead nucleic-acid viability staining
The LIVE/DEAD bacterial viability staining method is based on differential permeability of nucleic-acid-binding fluorescent dyes, most commonly SYTO 9 and propidium iodide (PI), which enables discrimination of bacterial populations with intact versus compromised cytoplasmic membranes. SYTO 9 penetrates both intact and damaged bacterial membranes and binds nucleic acids to produce green fluorescence, whereas propidium iodide penetrates only cells with compromised membranes and fluoresces red while also reducing SYTO 9 signal through competitive binding and fluorescence interactions. The resulting fluorescence pattern is interpreted as a proxy for membrane integrity, which is widely used as an indicator of bacterial viability in microscopy, flow cytometry, and spectroscopic platforms. However, mechanistic studies show that SYTO 9 and PI interactions involve displacement and fluorescence resonance energy transfer effects, which can influence signal interpretation depending on dye ratios a
Purity & Documentation
References
[2]. Vu TT, et al. Antibacterial activity of tannins isolated from Sapium baccatum extract and use for control of tomato bacterial wilt. PLoS One. 2017;12(7):e0181499. Published 2017 Jul 25. [Content Brief]
[3]. Khalifa I, et al. Tannins inhibit SARS-CoV-2 through binding with catalytic dyad residues of 3CLpro: An in silico approach with 19 structural different hydrolysable tannins. J Food Biochem. 2020 Oct;44(10):e13432. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tercatain Related Classifications
HY-N19923 Related Classifications
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Keywords
- Tercatain
- 103744-87-2
- SARS-CoV
- Bacterial
- Virus Protease
- Xanthomonas arboricola pv. pruni
- Acidovorax avenae subsp. cattleyae
- Cys145
- Pseudomonas syringae pv. actinidiae
- His41
- COVID-19 main protease
- Burkholderia glumae
- Ralstonia solanacearum
- SARS-CoV-2 3CLpro
- SARS-CoV-2 3-chymotrypsin-like cysteine protease
- Inhibitor
- inhibitor
- inhibit