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  4. Thyroglobulin

Thyroglobulin  (Synonyms: Thyroglobulin from bovine)

Cat. No.: HY-107903 Purity: 93%
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Handling Instructions Technical Support

Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle. Thyroglobulin activates Akt kinase activity in FRTL-5 thyroid cell.

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Thyroglobulin

Thyroglobulin Chemical Structure

CAS No. : 9010-34-8

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Thyroglobulin Related Antibodies

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Description

Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle. Thyroglobulin activates Akt kinase activity in FRTL-5 thyroid cell[1].

IC50 & Target

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In Vitro

Thyroglobulin (0-10 mg/mL; 12 h to 5 days) stimulates cell growth and DNA synthesis in quiescent FRTL-5 thyroid cells, with maximal activity at 5 mg/mL and reduced activity at higher concentrations[1].
Thyroglobulin (5 mg/mL; 12 h) does not increase cAMP levels in FRTL-5 thyroid cells[1].
Thyroglobulin (5 mg/mL; 30-180 min) activates Akt kinase activity in FRTL-5 thyroid cells within 30 min[1].
Thyroglobulin (0-10 mg/mL) suppresses TPO promoter activity in FRTL-5 thyroid cells in vitro in a concentration-dependent manner[1].
Thyroglobulin (0-10 mg/mL; 24 h) modulates PDS mRNA expression in FRTL-5 thyroid cells, with maximal expression at 5 mg/mL and reduced expression at higher concentrations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thyroglobulin Related Antibodies

Cell Proliferation Assay[1]

Cell Line: rat FRTL-5 thyroid cells
Concentration: 5 mg/mL (cell counting; maximal ³H-TdR incorporation); 0-10 mg/mL (³H-TdR concentration dependence)
Incubation Time: up to 5 days (cell counting); 12 h (³H-TdR incorporation)
Result: Increased cell number to levels comparable to complete medium (TSH + insulin + 5% serum) over 5 days using 5 mg/mL. Maximized ³H-TdR incorporation at 5 mg/mL, and reduced incorporation at 10 mg/mL.
Clinical Trial
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

[Thyroglobulin]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 93%

SDS (251 KB)

COA (241 KB)

Handling Instructions (2659 KB)
References
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Thyroglobulin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thyroglobulin9010-34-8Thyroglobulin from bovineBiochemical Assay Reagentsapical iodide transporterFRTL-5 thyroid cellsAkt kinaseendoplasmic reticulumcongenital hypothyroidism293T cellsER chaperonesnontoxic nodular goiterthyroid hormone biosynthesisInhibitorinhibitorinhibit

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