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Referencia número: HY-188010

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TLR8 agonist 11

TLR8 agonist 11 is a selective human Toll-like receptor 8 (TLR8) agonist. TLR8 agonist 11 activates the hTLR8-dependent NF-κB signaling pathway. TLR8 agonist 11 can be used for the research of inflammation and immune-related diseases.

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No. CAS: 1449680-12-9
Fòrmula: C₁₆H₁₈N₂O
Peso molecular:254.33

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Please store the product under the recommended conditions in the Certificate of Analysis.

TLR8 agonist 11 Chemical Structure

No. CAS: 1449680-12-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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^[1]

hTLR8

NF-κB

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In Vitro

Innate Immunity

TLR8 agonist 11 (compound 8e) is a human TLR8-specific agonist. It exhibits lower potency than its C2-butyl analog (compound 8d) and shows biphasic NF-κB induction characteristics in TLR8-transfected HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Inflammation-related Diseases

Chemical Information

No. CAS 1449680-12-9
Peso molecular 254.33
Fòrmula C₁₆H₁₈N₂O
SMILES

CCCCCC1=CC(C2=CC=CC=C2N=C3N)=C3O1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

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Instrucciones de manejo (2659 KB)

Referencias

[1]. Kokatla HP, et al. Exquisite selectivity for human toll-like receptor 8 in substituted furo[2,3-c]quinolines. J Med Chem. 2013 Sep 12;56(17):6871-85.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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TLR8 agonist 11

Ver todos los productos específicos de isoformas Toll-like Receptor (TLR)

Ver todos los productos específicos de isoformas NF-κB

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