TRAP-6-IN-1
TRAP-6-IN-1 (Compound 8) is a dual collagen and TRAP-6 inhibitor with IC50 values of 17.12 µM and 11.88 µM against collagen and TRAP-6, respectively. TRAP-6-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner.
For research use only. We do not sell to patients.
- CAS No.: 2068737-10-8
- Formula: C18H20O3
- Molecular Weight:284.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 11.88 µM (TRAP-6), 17.12 µM (collagen)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Platelet | IC50 |
11.88 μM
Compound: 8
|
Inhibition of TRAP6-induced platelet aggregation in human platelet preincubated for 5 mins followed by TRAP6-stimulation and measured after 6 mins by lumi-aggregometric method
Inhibition of TRAP6-induced platelet aggregation in human platelet preincubated for 5 mins followed by TRAP6-stimulation and measured after 6 mins by lumi-aggregometric method
|
[PMID: 32155530] |
| Platelet | IC50 |
17.12 μM
Compound: 8
|
Inhibition of collagen-induced platelet aggregation in human platelet preincubated for 5 mins followed by collagen-stimulation and measured after 6 mins by lumi-aggregometric method
Inhibition of collagen-induced platelet aggregation in human platelet preincubated for 5 mins followed by collagen-stimulation and measured after 6 mins by lumi-aggregometric method
|
[PMID: 32155530] |
Chemical Information
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CAS No. 2068737-10-8
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Molecular Weight 284.35
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Formula C18H20O3
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SMILES
CCC1(CC)C=CC2=O[H]OC3=C2C1=C(C4=C3CC=CC4)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)