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Cat. No.: HY-W273493

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4-Nitrochalcone

(Synonyms: 2-(4-Nitrobenzylidene)acetophenone)

4-Nitrochalcone (2-(4-Nitrobenzylidene)acetophenone) inhibits the proteasome, inhibits NF-κB activity induced by TNFα.

For research use only. We do not sell to patients.

CAS No.: 1222-98-6
Formula: C₁₅H₁₁NO₃
Molecular Weight:253.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

4-Nitrochalcone Chemical Structure

CAS No.: 1222-98-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

4-Nitrochalcone (2-(4-Nitrobenzylidene)acetophenone) inhibits the proteasome, inhibits NF-κB activity induced by TNFα^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	GI₅₀	7.5 μM Compound: 3	Antiproliferative activity against human A2780 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay Antiproliferative activity against human A2780 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay	[PMID: 34262643]
CAL-51	GI₅₀	1.21 μM Compound: SSE14104	Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay	[PMID: 28743509]
CCRF-CEM	IC₅₀	13.8 μM Compound: 4f	Inhibitory concentration against CEM T-lymphocytes Inhibitory concentration against CEM T-lymphocytes	[PMID: 12086496]
HCT-116	GI₅₀	3.13 μM Compound: SSE14104	Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay	[PMID: 28743509]
HeLa	IC₅₀	>20 μM Compound: 8c	Antiproliferative activity against human HeLa cells after 72 hrs by trypan blue assay Antiproliferative activity against human HeLa cells after 72 hrs by trypan blue assay	[PMID: 19155103]
HepG2	IC₅₀	64.7 μM Compound: 5	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 22658085]
HL-60	IC₅₀	6 μM Compound: 8c	Antiproliferative activity against human HL60 cells after 72 hrs by trypan blue assay Antiproliferative activity against human HL60 cells after 72 hrs by trypan blue assay	[PMID: 19155103]
HT-29	GI₅₀	15.5 μM Compound: 3	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay	[PMID: 34262643]
L1210	IC₅₀	59.1 μM Compound: 4f	Inhibitory activity against L1210 leukemia cells Inhibitory activity against L1210 leukemia cells	[PMID: 12086496]
MSTO-211H	GI₅₀	>20 μM Compound: 3	Antiproliferative activity against human MSTO-211H cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay Antiproliferative activity against human MSTO-211H cells assessed as cell growth inhibition measured after 72 hrs by trypan blue assay	[PMID: 34262643]
P388	IC₅₀	7.58 μM Compound: 4f	Inhibitory activity against Murine P388 cells Inhibitory activity against Murine P388 cells	[PMID: 12086496]
RBL-1	IC₅₀	23 μM Compound: 21	Inhibition of 5-lipoxygenase in rat RBL1 cells Inhibition of 5-lipoxygenase in rat RBL1 cells	10.1007/s00044-013-0745-7
RBL-1	IC₅₀	23 μM Compound: 21	Inhibition of cyclooxygenase in rat RBL1 cells Inhibition of cyclooxygenase in rat RBL1 cells	10.1007/s00044-013-0745-7

Chemical Information

CAS No. 1222-98-6
Molecular Weight 253.25
Formula C₁₅H₁₁NO₃
SMILES

O=C(C1=CC=CC=C1)/C=C/C2=CC=C(N(=O)=O)C=C2
Synonyms

2-(4-Nitrobenzylidene)acetophenone
Structure Classification
- Others
Initial Source
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Claudia Martins Galindo, et al. 4-Nitrochalcone as a potential drug in non-clinical breast cancer studies. Chem Biol Interact. 2024 Jan 5:387:110790. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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