FBP1 - fructose-bisphosphatase 1 Gene

Also Known as FBP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2203

About FBP1

Cytogenetic location: 9q22.32 Genomic coordinates (GRCh38): 9:94,603,133-94,640,263 (from NCBI)

This gene has 5 transcripts (splice variants), 143 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in liver (RPKM 175.9), kidney (RPKM 118.4) and 9 other tissues.

Summary

Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]

FBP1 Products (2)

mRNA	Protein	Name
NM_000507.4	NP_000498.2	fructose-1,6-bisphosphatase 1
NM_001127628.2	NP_001121100.1	fructose-1,6-bisphosphatase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables AMP binding	IDA IDA: Inferred from direct assay	8387495	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IMP IMP: Inferred from mutant phenotype	25043030	GOA
enables fructose 1,6-bisphosphate 1-phosphatase activity	IDA IDA: Inferred from direct assay	8387495	GOA
enables fructose 1,6-bisphosphate 1-phosphatase activity	IMP IMP: Inferred from mutant phenotype	7558035	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
enables metal ion binding	IMP IMP: Inferred from mutant phenotype	8387495	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8387495	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to magnesium ion	IDA IDA: Inferred from direct assay	10222032	GOA
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	16442285	GOA
involved in dephosphorylation	IDA IDA: Inferred from direct assay	8387495	GOA
involved in dephosphorylation	IMP IMP: Inferred from mutant phenotype	7558035	GOA
involved in fructose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	8387495	GOA
involved in gluconeogenesis	IMP IMP: Inferred from mutant phenotype	19259699	GOA
involved in negative regulation of Ras protein signal transduction	IDA IDA: Inferred from direct assay	19881551	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	19881551	GOA
involved in negative regulation of glycolytic process	IDA IDA: Inferred from direct assay	19881551	GOA
involved in negative regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	25043030	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25043030	GOA
involved in regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	7558035	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20096900	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	25043030	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBP1 Protein Structure

FBPase

0
100
200
300
338 a.a.

Protein Preferred Names	Protein Names
fructose-1,6-bisphosphatase 1	D-fructose-1,6-bisphosphate 1-phosphohydrolase 1

FBP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FBP1	P09467	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	25043030
Intra	FBP1	P09467	HIF1A	Homo sapiens	Q16665	Pull Down	25043030
Intra	FBP1	P09467	EPAS1	Homo sapiens	Q99814	Anti Bait CoIP	25043030
Intra	FBP1	P09467	EPAS1	Homo sapiens	Q99814	Pull Down	25043030
Intra	FBP1	P09467	EPAS1	Homo sapiens	Q99814	Anti Tag CoIP	25043030
Intra	FBP1	P09467	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	FBP1	P09467	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	FBP1	P09467	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	Validated Y2H	25910212
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Array	31515488
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Bait-Prey Pool	25910212
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Pooling	16169070
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	SLC	25910212
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	Validated Y2H	32296183
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Array	25502805
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Array	25910212
Intra	FBP1	P09467	FBP2	Homo sapiens	O00757	Validated Y2H	25910212
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Pooling	16189514
Intra	FBP1	P09467	FBP2	Homo sapiens	O00757	Y2H Array	31515488
Intra	FBP1	P09467	FBP2	Homo sapiens	O00757	Y2H Bait-Prey Pool	25910212
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Array	25416956
Intra	FBP1	P09467	FBP2	Homo sapiens	O00757	SLC	25910212
Intra	FBP1	P09467	FBP2	Homo sapiens	O00757	Y2H Array	25910212
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Prey Pooling	32296183
Intra	FBP1	P09467	FBP2	Homo sapiens	O00757	Anti Tag CoIP	33961781
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Array	32296183
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H Prey Pooling	25416956
Intra	FBP1	P09467	FBP1	Homo sapiens	P09467	Y2H	21516116
Intra	FBP1	P09467	FBP2	Homo sapiens	O00757	Y2H Prey Pooling	25416956
Intra	FBP1	P09467	FBP2	Homo sapiens	O00757	Y2H Array	25416956
Intra	FBP1	P09467	BIN1	Homo sapiens	O00499	Peptide Array	16275660
Intra	FBP1	P09467	BIN1	Homo sapiens	O00499	Y2H	16275660
Intra	FBP1	P09467	FXR2	Homo sapiens	P51116	Y2H Array	31515488
Intra	FBP1	P09467	FXR2	Homo sapiens	P51116	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FBP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70275	FBP1 Protein, Human (HEK293, His)	P09467 (A2-Q338)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Fructose-1,6-Bisphosphatase Deficiency	Fructose-1,6-Diphosphatase Deficiency Baker-Winegrad Disease FBP1D Fbpase Deficiency Fructose 1,6 Diphosphatase Deficiency Fructose 1 Phosphate Aldolase Deficiency Fbp1 Deficiency Hereditary Fructose Intolerance Syndrome
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome
Metabolic Acidosis
Lactic Acidosis	Acidosis, Lactic Acidosis Lactic
Acute Pyelonephritis	Apn - [Acute Pyelonephritis]
Glycogen Storage Disease Ia	Von Gierke Disease Glycogen Storage Disease Type I Glycogen Storage Disease I Hepatorenal Form Of Glycogen Storage Disease Hepatorenal Glycogenosis Glucose-6-Phosphatase Deficiency Glycogen Storage Disease, Type I Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ia GSD1A Gsd1 Von Gierke'S Disease Glycogen Storage Disease Type 1a Glycogen Storage Disease 1a Glucose-6-Phosphate Transport Defect Gsd Ia Deficiency Of Glucose-6-Phosphatase Glycogenosis Type I Glucose-6-Phosphatase Deficiency Glycogen Storage Disease Glycogenosis Type 1 Glucose-6-Phosphate Deficiency Gsd I Gsd Type I G6p Deficiency Type 1a Gsd Due To G6p Deficiency Type 1a Gsd Due To G6p Deficiency Type Ia Gsd Type 1a Gsdia Glycogen Storage Disease Due To G6p Deficiency Type Ia Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1a Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type Ia Glycogenosis Type Ia Gsd-Ia Storage Disease, Glycogen, Type 1a Glycogen Storage Disease Type Ia
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16309	MB-07803	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16307	MB05032	Inhibitor	99.63%	Unkown
HY-RS17537	Fbp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04779	FBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16758	Folr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17637	Fbp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23197	Folr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23994	Fbp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FBP1	MGD	MGI:95492
Rattus norvegicus	FBP1	RGD	RGD:2595
Bos taurus	FBP1	VGNC	VGNC:28887
Felis catus	FBP1	VGNC	VGNC:62172
Canis familiaris	FBP1	VGNC	VGNC:40757
Macaca mulatta	FBP1	VGNC	VGNC:72625
Others	FBP1	NCBI