NNMT - nicotinamide N-methyltransferase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4837

About NNMT

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:114,257,806-114,313,536 (from NCBI)

This gene has 8 transcripts (splice variants), 142 orthologues and 2 paralogues. Biased expression in liver (RPKM 188.3), appendix (RPKM 69.3) and 10 other tissues.

Summary

N-methylation is one method by which drug and Other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]

NNMT Products (4)

mRNA Protein Name
NM_001372045.1 NP_001358974.1 nicotinamide N-methyltransferase
NM_001372046.1 NP_001358975.1 nicotinamide N-methyltransferase
NM_001372047.1 NP_001358976.1 nicotinamide N-methyltransferase
NM_006169.3 NP_006160.1 nicotinamide N-methyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables nicotinamide N-methyltransferase activity IDA
IDA: Inferred from direct assay
8182091 GOA
enables nicotinamide N-methyltransferase activity IMP
IMP: Inferred from mutant phenotype
23455543 GOA
Biological Process GO Annotation Evidence References Source
involved in nicotinamide metabolic process IDA
IDA: Inferred from direct assay
8182091 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NNMT Protein Structure

NNMT_PNMT_TEMT

NNMT_PNMT_TEMT: NNMT/PNMT/TEMT family (2 - 259)

  • 0
  • 100
  • 200
  • 264 a.a.
Protein Preferred Names Protein Names

nicotinamide N-methyltransferase

Recombinant NNMT Proteins

Cat. No. Product Name Accession Purity
HY-P79286 Nicotinamide N-Methyltransferase/NNMT Protein, Human (His) P40261 (M1-L264) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pellagra

  • Niacin Deficiency

  • Niacin-Tryptophan Deficiency

  • Pellagroid Syndrome
Inflammatory Bowel Disease 25

  • Early Onset Autosomal Recessive Inflammatory Bowel Disease 25

  • Ibd25

  • Inflammatory Bowel Disease 25, Autosomal Recessive
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138993A NNMT-IN-6 hydrochloride Inhibitor 99.75% Unkown
HY-138993 NNMT-IN-6 Inhibitor / Unkown
HY-151500C JBSNF-000028 Inhibitor / Unkown
HY-186163 CC-410 Inhibitor / Unkown
HY-111367 MS2734 Inhibitor / Unkown
HY-W1006754 NNMT-IN-7 Inhibitor 98.0% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NNMT MGD MGI:1099443
Macaca mulatta NNMT VGNC VGNC:75362
Rattus norvegicus NNMT RGD RGD:1309606
Canis familiaris NNMT VGNC VGNC:43869
Others NNMT NCBI