RASSF2 - Ras association domain family member 2 Gene

Also Known as CENP-34; RASFADIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9770

About RASSF2

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:4,780,023-4,823,608 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 5 paralogues. Broad expression in brain (RPKM 57.7), bone marrow (RPKM 38.0) and 16 other tissues.

Summary

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]

RASSF2 Products (2)

mRNA Protein Name
NM_014737.3 NP_055552.1 ras association domain-containing protein 2
NM_170774.2 NP_739580.1 ras association domain-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12732644 GOA
enables protein kinase activity IGI
IGI: Inferred from genetic interaction
19962960 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
19962960 GOA
acts upstream of or within positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
19962960 GOA
acts upstream of or within positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
19962960 GOA
acts upstream of or within positive regulation of protein autophosphorylation IDA
IDA: Inferred from direct assay
19962960 GOA
acts upstream of or within positive regulation of protein kinase activity IDA
IDA: Inferred from direct assay
19962960 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
19525978 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19525978 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
20813266 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19525978 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
19962960 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASSF2 Protein Structure

RA

RA: Ras association (RalGDS/AF-6) domain (180 - 264)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

ras association domain-containing protein 2

  • Ras association (RalGDS/AF-6) domain family 2

RASSF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RASSF2 P50749 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
RASSF2 P50749 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
RASSF2 P50749 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
RASSF2 P50749 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
RASSF2 P50749 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
RASSF2 P50749 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
RASSF2 P50749 S100Z Homo sapiens Q8WXG8
Y2H Prey Pooling
32296183
Intra
RASSF2 P50749 S100Z Homo sapiens Q8WXG8
Y2H Array
32296183
Intra
RASSF2 P50749 S100Z Homo sapiens Q8WXG8
Validated Y2H
32296183
Intra
RASSF2 P50749 SUV39H1 Homo sapiens O43463
Y2H
23455924
Intra
RASSF2 P50749 SUV39H1 Homo sapiens O43463
Anti Tag CoIP
23455924
Intra
RASSF2 P50749 STK4 Homo sapiens Q13043
Anti Tag CoIP
24366813
Intra
RASSF2 P50749 STK4 Homo sapiens Q13043
Anti Tag CoIP
33961781
Intra
RASSF2 P50749 STK4 Homo sapiens Q13043
Anti Tag CoIP
24255178
Intra
RASSF2 P50749 STK4 Homo sapiens Q13043
BioID
24255178
Intra
RASSF2 P50749 KDM1A Homo sapiens O60341
Anti Tag CoIP
23455924
Intra
RASSF2 P50749 KDM1A Homo sapiens O60341
Y2H
23455924
Intra
RASSF2 P50749 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
RASSF2 P50749 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
RASSF2 P50749 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
RASSF2 P50749 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
RASSF2 P50749 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
RASSF2 P50749 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
RASSF2 P50749 STK3 Homo sapiens Q13188
BioID
24255178
Intra
RASSF2 P50749 STK3 Homo sapiens Q13188
Anti Tag CoIP
24255178
Intra
RASSF2 P50749 STK3 Homo sapiens Q13188
Anti Tag CoIP
33961781
Intra
RASSF2 P50749 STK3 Homo sapiens Q13188
Anti Tag CoIP
24366813
Intra
RASSF2 P50749 STK3 Homo sapiens Q13188
Anti Tag CoIP
28514442
Intra
RASSF2 P50749 STK3 Homo sapiens Q13188
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RASSF2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82089 RASSF2 Antibody (YA1834) WB Human
HY-P82089A RASSF2 Antibody (YA1834)(PBS only) WB Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11702 RASSF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RASSF2 VGNC VGNC:45380
Macaca mulatta RASSF2 VGNC VGNC:76674
Mus musculus RASSF2 MGD MGI:2442060
Felis catus RASSF2 VGNC VGNC:69253
Rattus norvegicus RASSF2 RGD RGD:1305551
Bos taurus RASSF2 VGNC VGNC:33758
Others RASSF2 NCBI