G3BP2 - G3BP stress granule assembly factor 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9908

About G3BP2

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,642,786-75,724,437 (from NCBI)

This gene has 90 transcripts (splice variants), 225 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 45.6), thyroid (RPKM 35.2) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in positive regulation of stress granule assembly and protein homooligomerization. Located in cytoplasmic stress granule and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

G3BP2 Products (21)

mRNA Protein Name
NM_001400004.1 NP_001386933.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400005.1 NP_001386934.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400006.1 NP_001386935.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400007.1 NP_001386936.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400008.1 NP_001386937.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400010.1 NP_001386939.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400011.1 NP_001386940.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400012.1 NP_001386941.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400013.1 NP_001386942.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400014.1 NP_001386943.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400015.1 NP_001386944.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400016.1 NP_001386945.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400017.1 NP_001386946.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400018.1 NP_001386947.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400019.1 NP_001386948.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400020.1 NP_001386949.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400021.1 NP_001386950.1 ras GTPase-activating protein-binding protein 2 isoform c
NM_001400022.1 NP_001386951.1 ras GTPase-activating protein-binding protein 2 isoform d
NM_012297.5 NP_036429.2 ras GTPase-activating protein-binding protein 2 isoform a
NM_203504.3 NP_987100.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_203505.3 NP_987101.1 ras GTPase-activating protein-binding protein 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular condensate scaffold activity IDA
IDA: Inferred from direct assay
32302570 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of stress granule assembly IMP
IMP: Inferred from mutant phenotype
23279204 GOA
involved in protein homooligomerization IMP
IMP: Inferred from mutant phenotype
23279204 GOA
involved in stress granule assembly IDA
IDA: Inferred from direct assay
27022092 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic stress granule IMP
IMP: Inferred from mutant phenotype
23279204 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

G3BP2 Protein Structure

NTF2

NTF2: Nuclear transport factor 2 (NTF2) domain (11 - 133)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (333 - 390)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 482 a.a.
Protein Preferred Names Protein Names

ras GTPase-activating protein-binding protein 2

  • G3BP-2

G3BP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
G3BP2 Q9UN86 USP10 Homo sapiens Q14694
Anti Bait CoIP
34901782
Intra
G3BP2 Q9UN86 USP10 Homo sapiens Q14694
FPS
34799561
Intra
G3BP2 Q9UN86 USP10 Homo sapiens Q14694
Anti Tag CoIP
19615732
Intra
G3BP2 Q9UN86 USP10 Homo sapiens Q14694
Anti Tag CoIP
35271311
Intra
G3BP2 Q9UN86 USP10 Homo sapiens Q14694
Y2H Array
31515488
Intra
G3BP2 Q9UN86 USP10 Homo sapiens Q14694
Y2H Prey Pooling
25416956
Cross
G3BP2 Q9UN86 N SARS-CoV-2 P0DTC9
FPS
34799561
Cross
G3BP2 Q9UN86 N SARS-CoV-2 P0DTC9
Pull Down
34400613
Cross
G3BP2 Q9UN86 Twist1 Mus musculus P26687
Anti Tag CoIP
25893917
Cross
G3BP2 Q9UN86 Twist1 Mus musculus P26687
Anti Bait CoIP
25893917
Cross: Cross-species interaction Intra: Intraspecies interaction

G3BP2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810965 G3BP2 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Mouth Disease

  • Mouth Diseases

  • Mouth Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131649 Compound C108 Inhibitor 99.32% Unkown
HY-170872 PT-129 98.66% Unkown
HY-RS05190 G3BP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160706 HHQ16 99.97% Unkown
HY-174329 MRT-5702D / Unkown
HY-RS20411 G3bp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26920 G3bp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta G3BP2 VGNC VGNC:100229
Bos taurus G3BP2 VGNC VGNC:29177
Mus musculus G3BP2 MGD MGI:2442040
Felis catus G3BP2 VGNC VGNC:78500
Rattus norvegicus G3BP2 RGD RGD:1309571
Canis familiaris G3BP2 VGNC VGNC:41039
Others G3BP2 NCBI