GR 94800
Based on 1 Customer Validation
GR 94800 is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively.
For research use only. We do not sell to patients.
- Purity: 99.42%
- CAS No.: 141636-65-9
- Formula: C49H61N9O8
- Molecular Weight:904.06
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Responses to EFS (15 Hz) were significantly reduced by the NK2 receptor antagonist GR 94800 (1 μM) either alone or in combination with the NK1 antagonist (1 μM)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 141636-65-9
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Appearance Solid
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Molecular Weight 904.06
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Formula C49H61N9O8
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Color White to off-white
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Sequence Shortening
Bz-AA-{D-Trp}-F-{D-Pro}-P-{Nle}-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (110.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. A B McElroy, et al. Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J Med Chem. 1992 Jul 10;35(14):2582-91. [Content Brief]
[2]. M A Matuszek, et al. An investigation of tachykinin NK2 receptor subtypes in the rat. Eur J Pharmacol. 1998 Jul 3;352(1):103-9. [Content Brief]
[3]. Stephen D Tichenor, et al. Excitatory motor innervation in the canine rectoanal region: role of changing receptor populations. Br J Pharmacol. 2002 Dec;137(8):1321-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1061 mL | 5.5306 mL | 11.0612 mL | 27.6530 mL |
| 5 mM | 0.2212 mL | 1.1061 mL | 2.2122 mL | 5.5306 mL | |
| 10 mM | 0.1106 mL | 0.5531 mL | 1.1061 mL | 2.7653 mL | |
| 15 mM | 0.0737 mL | 0.3687 mL | 0.7374 mL | 1.8435 mL | |
| 20 mM | 0.0553 mL | 0.2765 mL | 0.5531 mL | 1.3827 mL | |
| 25 mM | 0.0442 mL | 0.2212 mL | 0.4424 mL | 1.1061 mL | |
| 30 mM | 0.0369 mL | 0.1844 mL | 0.3687 mL | 0.9218 mL | |
| 40 mM | 0.0277 mL | 0.1383 mL | 0.2765 mL | 0.6913 mL | |
| 50 mM | 0.0221 mL | 0.1106 mL | 0.2212 mL | 0.5531 mL | |
| 60 mM | 0.0184 mL | 0.0922 mL | 0.1844 mL | 0.4609 mL | |
| 80 mM | 0.0138 mL | 0.0691 mL | 0.1383 mL | 0.3457 mL | |
| 100 mM | 0.0111 mL | 0.0553 mL | 0.1106 mL | 0.2765 mL |
GR 94800 Related Classifications
HY-P1277 Related Classifications
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