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Cat. No.: HY-100843

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L-AP6

L-AP6 is a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.

For research use only. We do not sell to patients.

CAS No.: 78944-89-5
Formula: C₆H₁₄NO₅P
Molecular Weight:211.15

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

L-AP6 Chemical Structure

CAS No.: 78944-89-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

L-AP6 is a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Pyramidal neuron	IC₅₀	0.17 μM Compound: L-AP6	sensitization of CA1 pyramidal neurons to depolarizations by L-AP6 after exposure to quisqualic acid sensitization of CA1 pyramidal neurons to depolarizations by L-AP6 after exposure to quisqualic acid	[PMID: 7966155]
Pyramidal neuron	IC₅₀	11 μM Compound: L-AP6	sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 before exposure to quisqualic acid sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 before exposure to quisqualic acid	[PMID: 7966155]
Pyramidal neuron	IC₅₀	12 μM Compound: L-AP6	sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 after reversal with L-alpha-AA sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 after reversal with L-alpha-AA	[PMID: 7966155]

Chemical Information

CAS No. 78944-89-5
Appearance Solid
Molecular Weight 211.15
Formula C₆H₁₄NO₅P
Color White to off-white
SMILES

NC(CCCCP(O)(O)=O)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Schulte MK, et, al. Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 1994 Jun 27;649(1-2):203-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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