PSB-12379
Based on 5 publication(s) in Google Scholar
PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).
For research use only. We do not sell to patients.
- Purity : 99.96%
- CAS No.: 1802226-78-3
- Formula: C18H23N5O9P2
- Molecular Weight:515.35
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-125286
AB-680CD73 Inhibitor -
HY-103695
CD73-IN-1CD73 Inhibitor -
HY-B0228
AdenosineEndogenous Autacoid -
HY-137246
CD73-IN-3CD73 Inhibitor -
HY-103160A
EHNA hydrochloridePDE2 Inhibitor -
HY-10181
DasatinibSrc/Bcr-Abl Inhibitor -
HY-70062
PevonedistatNAE Inhibitor -
HY-W010936
NitrobenzylthioinosineENT1 Transporter Inhibitor -
HY-B0312
DipyridamolePDE Inhibitor -
HY-145334
CD73-IN-5CD73 Inhibitor -
HY-13677
6-Mercaptopurine -
HY-103259
Sodium metatungstateNTPDase Inhibitor
Publications Citing Use of MedChemExpress (MCE) PSB-12379
More
Biological Activity
Description
IC50 & Target
Ki: 9.03 nM (rat), 2.21 nM (human) (Ecto-5’-Nucleotidase)[1]
In Vitro
Metabolism: Only a small percentage (<23%) of PSB-12379 (10g) is metabolized under the applied conditions, while >77% of the compounds are recovered unchanged after a long incubation for 8 h. PSB-12379 (10g) is somewhat less stable, and 56% are metabolized within 8 h. Hydrolytic cleavage of the glycosidic bond, which is a typical phase I reaction of nucleosides and nucleotides, was observed as the main reaction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
-
CAS No. 1802226-78-3
-
Appearance Solid
-
Molecular Weight 515.35
-
Formula C18H23N5O9P2
-
Color White to off-white
-
SMILES
O=P(O)(O)CP(OC[C@H]1O[C@@H](N2C=NC3=C(NCC4=CC=CC=C4)N=CN=C32)[C@H](O)[C@@H]1O)(O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
-
Journal Impact Factor
-
Most Recent
-
Front Bioeng Biotechnol
CD73-Positive Small Extracellular Vesicles Derived From Umbilical Cord Mesenchymal Stem Cells Promote the Proliferation and Migration of Pediatric Urethral Smooth Muscle Cells Through Adenosine Pathway. [Abstract]2022 Apr 27;10:895998. PMID: 35573239 -
Cancers (Basel)
Adenosine 2A Receptor Activation Amplifies Ibrutinib Antiplatelet Effect; Implications in Chronic Lymphocytic Leukemia. [Abstract]2022 Nov 23;14(23):5750. PMID: 36497231 -
bioRxiv
Efficient Generation of Functional TCRαβ+ Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation. [Abstract]2026 Apr 1:2026.03.31.715684. PMID: 41959015 -
-
Solvent & Solubility
In Vitro:
H2O : 125 mg/mL (242.55 mM; Need ultrasonic)
DMSO : ≥ 5 mg/mL (9.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (194.04 mM); Clear solution; Need ultrasonic
Purity & Documentation
-
Data Sheet (281 KB)
-
SDS (583 KB)
- English - EN (583 KB)
- Français - FR (583 KB)
- Deutsch - DE (583 KB)
- Norwegian - NO (583 KB)
- Español - ES (583 KB)
- Swedish - SV (583 KB)
- Italian - IT (583 KB)
- Korean - KR (583 KB)
- Portuguese - PT (583 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.9404 mL | 9.7021 mL | 19.4043 mL | 48.5107 mL |
| 5 mM | 0.3881 mL | 1.9404 mL | 3.8809 mL | 9.7021 mL | |
| H2O | 10 mM | 0.1940 mL | 0.9702 mL | 1.9404 mL | 4.8511 mL |
| 15 mM | 0.1294 mL | 0.6468 mL | 1.2936 mL | 3.2340 mL | |
| 20 mM | 0.0970 mL | 0.4851 mL | 0.9702 mL | 2.4255 mL | |
| 25 mM | 0.0776 mL | 0.3881 mL | 0.7762 mL | 1.9404 mL | |
| 30 mM | 0.0647 mL | 0.3234 mL | 0.6468 mL | 1.6170 mL | |
| 40 mM | 0.0485 mL | 0.2426 mL | 0.4851 mL | 1.2128 mL | |
| 50 mM | 0.0388 mL | 0.1940 mL | 0.3881 mL | 0.9702 mL | |
| 60 mM | 0.0323 mL | 0.1617 mL | 0.3234 mL | 0.8085 mL | |
| 80 mM | 0.0243 mL | 0.1213 mL | 0.2426 mL | 0.6064 mL | |
| 100 mM | 0.0194 mL | 0.0970 mL | 0.1940 mL | 0.4851 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PSB-12379 Related Classifications
HY-100747 Related Classifications
Powered by Bioz