Crepidatin
Crepidatin is a bibenzyl compound that can be isolated from the stems of Dendrobium loddigesii. Crepidatin promotes anoikis of lung cancer cells. Crepidatin inhibits the anchorage-independent growth of human lung cancer cells. Crepidatin can be used in lung cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 101508-50-3
- Formula: C18H22O5
- Molecular Weight:318.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H23 | IC50 |
157.77 μM
Compound: 12
|
Anti-cancer activity against human NCI-H23 cells
Anti-cancer activity against human NCI-H23 cells
|
[PMID: 32711292] |
Crepidatin (Compound 3) exhibits cytotoxic activity against H23 cells after 24 h, with an IC50 value of 157.77 μM[1].
Crepidatin (0-1 μM; 24 h) significantly enhances anoikis in H23 cells[1].
Crepidatin (0-1 μM; 4 weeks) significantly inhibits the anchorage-independent growth of H23 cells by reducing colony number and diameter[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H23 cells
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Concentration:0, 0.5, 1 μM
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Incubation Time:4 weeks (suspended soft agar culture)
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Result:Significantly reduced relative colony numbe and relative colony diamete compared to untreated control.
Further reduced relative colony number nd relative colony diameter compared to untreated control at 1 μM.
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Cell Line:H23 cells
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Concentration:0, 0.5, 1 μM
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Incubation Time:24 h
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Result:Caused significant enhancing effect on cell anoikis in a concentration-dependent manner.
Chemical Information
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CAS No. 101508-50-3
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Molecular Weight 318.36
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Formula C18H22O5
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SMILES
OC1=CC=C(CCC2=CC(OC)=C(C(OC)=C2)OC)C=C1OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)