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Cat. No.: HY-134648

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Ganfeborole

(Synonyms: GSK656 free base; GSK3036656 free base; GSK070 free base)

5 Cited Publications

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Based on 5 publication(s) in Google Scholar

Ganfeborole (GSK656 free base) is a potent, selective and orally active inhibitor of M. tuberculosis leucyl-tRNA synthetase, with an IC₅₀ of 0.20 μM. Ganfeborole can be used for the research of tuberculosis.

For research use only. We do not sell to patients.

CAS No.: 2131798-12-2
Formula: C₁₀H₁₃BClNO₄
Molecular Weight:257.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Ganfeborole Chemical Structure

CAS No.: 2131798-12-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 2131798-12-2
Molecular Weight 257.48
Formula C₁₀H₁₃BClNO₄
SMILES

OB1O[C@H](CN)C2=C(Cl)C=CC(OCCO)=C21
Synonyms

GSK656 free base; GSK3036656 free base; GSK070 free base
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

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Nat Nanotechnol

Nanofibrous supramolecular peptide hydrogels for controlled release of small-molecule drugs and biologics. [Abstract]

2025 Oct;20(10):1502-1513. PMID: 40931056
Antimicrob Agents Chemother

A Novel Leucyl-tRNA Synthetase Inhibitor, MRX-6038, Expresses Anti-Mycobacterium abscessus Activity In Vitro and In Vivo. [Abstract]

2022 Sep 20;66(9):e0060122. PMID: 35969055
Biofuel Bioprod Bior

2025 Sep 3;19(5):1378-1399.
ACS Chem Biol

Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. [Abstract]

2022 Jan 21;17(1):39-53. PMID: 34908399
bioRxiv

2024 May 23.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li X, et, al. Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). J Med Chem. 2017 Oct 12;60(19):8011-8026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
Publications (5)
Purity & Documentation
References

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Ganfeborole

Publications Citing Use of MedChemExpress (MCE) Ganfeborole