Ganfeborole
Based on 5 publication(s) in Google Scholar
Ganfeborole (GSK656 free base) is a potent, selective and orally active inhibitor of M. tuberculosis leucyl-tRNA synthetase, with an IC50 of 0.20 μM. Ganfeborole can be used for the research of tuberculosis.
For research use only. We do not sell to patients.
- CAS No.: 2131798-12-2
- Formula: C10H13BClNO4
- Molecular Weight:257.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Ganfeborole
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Biological Activity
Description
Chemical Information
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CAS No. 2131798-12-2
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Molecular Weight 257.48
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Formula C10H13BClNO4
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SMILES
OB1O[C@H](CN)C2=C(Cl)C=CC(OCCO)=C21
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Synonyms
GSK656 free base; GSK3036656 free base; GSK070 free base
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Nat Nanotechnol
Nanofibrous supramolecular peptide hydrogels for controlled release of small-molecule drugs and biologics. [Abstract]2025 Oct;20(10):1502-1513. PMID: 40931056 -
Antimicrob Agents Chemother
A Novel Leucyl-tRNA Synthetase Inhibitor, MRX-6038, Expresses Anti-Mycobacterium abscessus Activity In Vitro and In Vivo. [Abstract]2022 Sep 20;66(9):e0060122. PMID: 35969055 -
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ACS Chem Biol
Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. [Abstract]2022 Jan 21;17(1):39-53. PMID: 34908399 -
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)