NRCAM - neuronal cell adhesion molecule Gene

Also Known as NEDNMS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4897

About NRCAM

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:108,147,649-108,456,720 (from NCBI)

This gene has 14 transcripts (splice variants), 282 orthologues, 36 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 36.1), adrenal (RPKM 15.3) and 5 other tissues.

Summary

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin Cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

NRCAM Products (67)

mRNA Protein Name
NM_001037132.4 NP_001032209.1 neuronal cell adhesion molecule isoform A precursor
NM_001193582.2 NP_001180511.1 neuronal cell adhesion molecule isoform D precursor
NM_001193583.2 NP_001180512.1 neuronal cell adhesion molecule isoform E precursor
NM_001193584.2 NP_001180513.1 neuronal cell adhesion molecule isoform F precursor
NM_001371119.1 NP_001358048.1 neuronal cell adhesion molecule isoform P precursor
NM_001371122.1 NP_001358051.1 neuronal cell adhesion molecule isoform E precursor
NM_001371123.1 NP_001358052.1 neuronal cell adhesion molecule isoform G precursor
NM_001371124.1 NP_001358053.1 neuronal cell adhesion molecule isoform H precursor
NM_001371125.1 NP_001358054.1 neuronal cell adhesion molecule isoform I
NM_001371126.1 NP_001358055.1 neuronal cell adhesion molecule isoform H precursor
NM_001371127.1 NP_001358056.1 neuronal cell adhesion molecule isoform Q precursor
NM_001371128.1 NP_001358057.1 neuronal cell adhesion molecule isoform D precursor
NM_001371129.1 NP_001358058.1 neuronal cell adhesion molecule isoform J precursor
NM_001371130.1 NP_001358059.1 neuronal cell adhesion molecule isoform K precursor
NM_001371131.1 NP_001358060.1 neuronal cell adhesion molecule isoform A precursor
NM_001371132.1 NP_001358061.1 neuronal cell adhesion molecule isoform J precursor
NM_001371133.1 NP_001358062.1 neuronal cell adhesion molecule isoform B precursor
NM_001371134.1 NP_001358063.1 neuronal cell adhesion molecule isoform R precursor
NM_001371135.1 NP_001358064.1 neuronal cell adhesion molecule isoform S precursor
NM_001371136.1 NP_001358065.1 neuronal cell adhesion molecule isoform T precursor
NM_001371137.1 NP_001358066.1 neuronal cell adhesion molecule isoform U
NM_001371138.1 NP_001358067.1 neuronal cell adhesion molecule isoform V precursor
NM_001371139.1 NP_001358068.1 neuronal cell adhesion molecule isoform E precursor
NM_001371140.1 NP_001358069.1 neuronal cell adhesion molecule isoform W precursor
NM_001371141.1 NP_001358070.1 neuronal cell adhesion molecule isoform X precursor
NM_001371142.1 NP_001358071.1 neuronal cell adhesion molecule isoform Y
NM_001371143.1 NP_001358072.1 neuronal cell adhesion molecule isoform L
NM_001371144.1 NP_001358073.1 neuronal cell adhesion molecule isoform D precursor
NM_001371145.1 NP_001358074.1 neuronal cell adhesion molecule isoform Z precursor
NM_001371146.1 NP_001358075.1 neuronal cell adhesion molecule isoform aa precursor
NM_001371147.1 NP_001358076.1 neuronal cell adhesion molecule isoform I
NM_001371148.1 NP_001358077.1 neuronal cell adhesion molecule isoform M
NM_001371149.1 NP_001358078.1 neuronal cell adhesion molecule isoform G precursor
NM_001371150.1 NP_001358079.1 neuronal cell adhesion molecule isoform bb precursor
NM_001371151.1 NP_001358080.1 neuronal cell adhesion molecule isoform B precursor
NM_001371152.1 NP_001358081.1 neuronal cell adhesion molecule isoform K precursor
NM_001371153.1 NP_001358082.1 neuronal cell adhesion molecule isoform N precursor
NM_001371154.1 NP_001358083.1 neuronal cell adhesion molecule isoform O precursor
NM_001371155.1 NP_001358084.1 neuronal cell adhesion molecule isoform E precursor
NM_001371156.1 NP_001358085.1 neuronal cell adhesion molecule isoform cc precursor
NM_001371157.1 NP_001358086.1 neuronal cell adhesion molecule isoform dd precursor
NM_001371158.1 NP_001358087.1 neuronal cell adhesion molecule isoform ee precursor
NM_001371159.1 NP_001358088.1 neuronal cell adhesion molecule isoform ll precursor
NM_001371160.1 NP_001358089.1 neuronal cell adhesion molecule isoform ff precursor
NM_001371161.1 NP_001358090.1 neuronal cell adhesion molecule isoform N precursor
NM_001371162.1 NP_001358091.1 neuronal cell adhesion molecule isoform F precursor
NM_001371163.1 NP_001358092.1 neuronal cell adhesion molecule isoform E precursor
NM_001371164.1 NP_001358093.1 neuronal cell adhesion molecule isoform L
NM_001371165.1 NP_001358094.1 neuronal cell adhesion molecule isoform E precursor
NM_001371166.1 NP_001358095.1 neuronal cell adhesion molecule isoform O precursor
NM_001371167.1 NP_001358096.1 neuronal cell adhesion molecule isoform E precursor
NM_001371168.1 NP_001358097.1 neuronal cell adhesion molecule isoform D precursor
NM_001371169.1 NP_001358098.1 neuronal cell adhesion molecule isoform gg precursor
NM_001371170.1 NP_001358099.1 neuronal cell adhesion molecule isoform hh
NM_001371171.1 NP_001358100.1 neuronal cell adhesion molecule isoform B precursor
NM_001371172.1 NP_001358101.1 neuronal cell adhesion molecule isoform H precursor
NM_001371173.1 NP_001358102.1 neuronal cell adhesion molecule isoform ii precursor
NM_001371174.1 NP_001358103.1 neuronal cell adhesion molecule isoform jj precursor
NM_001371175.1 NP_001358104.1 neuronal cell adhesion molecule isoform kk precursor
NM_001371176.1 NP_001358105.1 neuronal cell adhesion molecule isoform K precursor
NM_001371177.1 NP_001358106.1 neuronal cell adhesion molecule isoform E precursor
NM_001371178.1 NP_001358107.1 neuronal cell adhesion molecule isoform B precursor
NM_001371179.1 NP_001358108.1 neuronal cell adhesion molecule isoform M
NM_001371180.1 NP_001358109.1 neuronal cell adhesion molecule isoform M
NM_001371181.1 NP_001358110.1 neuronal cell adhesion molecule isoform E precursor
NM_001371182.1 NP_001358111.1 neuronal cell adhesion molecule isoform mm precursor
NM_005010.5 NP_005001.3 neuronal cell adhesion molecule isoform B precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ankyrin binding IDA
IDA: Inferred from direct assay
14602817 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23897819 GOA
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IEP
IEP: Inferred from expression pattern
11866539 GOA
involved in central nervous system development IMP
IMP: Inferred from mutant phenotype
35108495 GOA
involved in clustering of voltage-gated sodium channels IDA
IDA: Inferred from direct assay
14602817 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRCAM Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (52 - 137)

Ig_3

Ig_3: Immunoglobulin domain (156 - 221)

I-set

I-set: Immunoglobulin I-set domain (284 - 357)

I-set

I-set: Immunoglobulin I-set domain (364 - 449)

I-set

I-set: Immunoglobulin I-set domain (465 - 542)

I-set

I-set: Immunoglobulin I-set domain (548 - 633)

fn3

fn3: Fibronectin type III domain (649 - 733)

fn3

fn3: Fibronectin type III domain (750 - 830)

fn3

fn3: Fibronectin type III domain (848 - 940)

fn3

fn3: Fibronectin type III domain (953 - 1037)

fn3

fn3: Fibronectin type III domain (1070 - 1143)

Bravo_FIGEY

Bravo_FIGEY: Bravo-like intracellular region (1191 - 1282)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1304 a.a.
Protein Preferred Names Protein Names

neuronal cell adhesion molecule

  • NgCAM-related cell adhesion molecule

Recombinant NRCAM Proteins

Cat. No. Product Name Accession Purity
HY-P71002 NRCAM Protein, Human (HEK293, Fc) AAI15737.1 (Q25-N600) ≥ 90%, as determined by reducing SDS-PAGE.

NRCAM Antibodies

Cat. No. Product Name Application Reactivity
HY-P82699 NrCAM Antibody (YA2444) WB, IP Human
HY-P84705 NrCAM Antibody (YA4402) ICC/IF, ELISA Human
HY-P84705A NrCAM Antibody (YA4402)(PBS only) ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Neuromuscular And Skeletal Abnormalities

  • NEDNMS
Masa Syndrome

  • L1 Syndrome

  • Crash Syndrome

  • X-Linked Hydrocephalus Syndrome

  • SPG1

  • Gareis-Mason Syndrome

  • Spastic Paraplegia 1, X-Linked

  • Corpus Callosum Hypoplasia-Retardation-Adducted Thumbs-Spasticity-Hydrocephalus Syndrome

  • L1cam Syndrome

  • Spastic Paraplegia 1

  • Mental Retardation, Aphasia, Shuffling Gait, And Adducted Thumbs

  • Clasped Thumb And Mental Retardation

  • Thumb, Congenital Clasped, With Mental Retardation

  • Adducted Thumb With Mental Retardation

  • Hereditary Spastic Paraplegia 1

  • X-Linked Complicated Hereditary Spastic Paraplegia Type 1

  • X-Linked Corpus Callosum Agenesis

  • X-Linked Spastic Paraplegia 1

  • L1 Disease

  • X-Linked Intellectual Disability - Corpus Callosum Agenesis - Spastic Quadriparesis

  • Adducted Thumb With Intellectual Disability

  • Clasped Thumb And Intellectual Disability

  • Intellectual Disability Aphasia Shuffling Gait Adducted Thumbs

  • Thumb Congenital Clasped With Intellectual Disability

  • X-Linked Intellectual Disability-Corpus Callosum Agenesis-Spastic Quadriparesis Syndrome

  • Adducted Thumbs-Mental Retardation Syndrome

  • Corpus Callosum Hypoplasia, Mental Retardation, Adducted Thumbs, Spastic Paraplegia, Hydrocephalus Syndrome

  • Mental Retardation-Clasped Thumb Syndrome

  • Intellectual Disability-Aphasia-Shuffling Gait-Adducted Thumbs Syndrome

  • Spastic Paraplegia Type 1, X-Linked

  • MASA

  • Corpus Callosum Hypoplasia-Psychomotor Retardation, Adducted Thumbs-Spastic Paraparesis-Hydrocephalus

  • Crash

  • Masa Syndrome
Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome

  • ACOGS
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Cortical Dysplasia, Complex, With Other Brain Malformations 1

  • Complex Cortical Dysplasia With Other Brain Malformations 1

  • CDCBM1

  • Cortical Dysgenesis With Pontocerebellar Hypoplasia Due To Tubb3 Mutation
Demyelinating Polyneuropathy

  • Peripheral Demyelinating Neuropathy

  • Demyelinating Peripheral Neuropathy
Hereditary Spastic Paraplegia

  • Familial Spastic Paraplegia

  • Hereditary Spastic Paraparesis

  • Strumpell-Lorrain Disease

  • Familial Spastic Paraparesis

  • Hsp

  • Spg

  • Strümpell-Lorrain Disease

  • Spastic Paraplegia, Hereditary

  • French Settlement Disease

  • Strumpell-Lorrain Syndrome

  • Fsp

  • Spastic Paraplegia, Familial

  • Spastic Paraplegia Hereditary

  • Spastic Paraplegia 3, Autosomal Dominant

  • Spastic Paraparesis

  • Hereditary Spastic Paralysis

  • Familial Spastic Paralysis

  • Hereditary Spastic Ataxia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09563 NRCAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20457 Nrcam Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26966 Nrcam Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NRCAM RGD RGD:3209
Felis catus NRCAM VGNC VGNC:80643
Macaca mulatta NRCAM VGNC VGNC:75525
Mus musculus NRCAM MGD MGI:104750
Bos taurus NRCAM VGNC VGNC:32257
Canis familiaris NRCAM VGNC VGNC:43963
Others NRCAM NCBI