UCHL3 - ubiquitin C-terminal hydrolase L3 Gene

Also Known as UCH-L3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7347

About UCHL3

Cytogenetic location: 13q22.2 Genomic coordinates (GRCh38): 13:75,549,502-75,606,020 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 5.1), testis (RPKM 4.9) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

UCHL3 Products (2)

mRNA	Protein	Name
NM_001270952.2	NP_001257881.1	ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 1
NM_006002.5	NP_005993.1	ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type deubiquitinase activity	EXP EXP: Inferred from Experiment	26235645	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	9521656	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	21762696	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	19154770	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein catabolic process	IDA IDA: Inferred from direct assay	21762696	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	9521656	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCHL3 Protein Structure

Peptidase_C12

0
100
200
230 a.a.

Protein Preferred Names	Protein Names
ubiquitin carboxyl-terminal hydrolase isozyme L3	testicular tissue protein Li 221

UCHL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UCHL3	P15374	CLPB	Homo sapiens	Q9H078	Anti Tag CoIP	33961781
Intra	UCHL3	P15374	CLPB	Homo sapiens	Q9H078	Anti Tag CoIP	19615732
Intra	UCHL3	P15374	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	UCHL3	P15374	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	UCHL3	P15374	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UCHL3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71115	UCHL3 Protein, Human (His)	P15374 (M1-A230)	≥ 95%, as determined by reducing SDS-PAGE.

UCHL3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83066	UCHL3 Antibody (YA2811)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18637	LDN-57444		99.21%	Unkown
HY-18638	TCID	Inhibitor	99.78%	Unkown
HY-133118	6RK73	Inhibitor	98.41%	Unkown
HY-149230	USP28-IN-4	Inhibitor	98.86%	Unkown
HY-149229	USP28-IN-3	Inhibitor	98.26%	Unkown
HY-149228	USP28-IN-2	Inhibitor	/	Unkown
HY-182636	MT16-001	Inhibitor	/	Unkown
HY-RS15401	UCHL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17309	Uchl3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23764	Uchl3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UCHL3	VGNC	VGNC:78706
Bos taurus	UCHL3	VGNC	VGNC:36632
Rattus norvegicus	UCHL3	RGD	RGD:1561196
Mus musculus	UCHL3	MGD	MGI:1355274
Felis catus	UCHL3	VGNC	VGNC:66796
Canis familiaris	UCHL3	VGNC	VGNC:48104
Others	UCHL3	NCBI