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SLC39A7 - solute carrier family 39 member 7 Gene

Also Known as KE4; AGM9; HKE4; ZIP7; RING5; H2-KE4; D6S115E; D6S2244E

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7922

About SLC39A7

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,200,867-33,204,437 (from NCBI)

This gene has 17 transcripts (splice variants), 1 gene allele, 175 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 58.8), placenta (RPKM 52.4) and 25 other tissues.

Summary

The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in Cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

SLC39A7 Products (3)

mRNA	Protein	Name
NM_001077516.2	NP_001070984.1	zinc transporter SLC39A7 isoform 1 precursor
NM_001288777.2	NP_001275706.1	zinc transporter SLC39A7 isoform 2
NM_006979.3	NP_008910.2	zinc transporter SLC39A7 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22317921	GOA
enables zinc ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	14525538	GOA
enables zinc ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	30718914	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	30718914	GOA
involved in intracellular zinc ion homeostasis	IMP IMP: Inferred from mutant phenotype	29980658	GOA
involved in regulation of ferroptosis	IMP IMP: Inferred from mutant phenotype	33608508	GOA
involved in zinc ion transmembrane transport	IDA IDA: Inferred from direct assay	14525538	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	14525538	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	29980658	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC39A7 Protein Structure

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469 a.a.

Protein Preferred Names	Protein Names
zinc transporter SLC39A7	HLA class II region expressed gene KE4

SLC39A7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC39A7	Q92504	LCE4A	Homo sapiens	Q5TA78	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	LCE4A	Homo sapiens	Q5TA78	Y2H Array	32296183
Intra	SLC39A7	Q92504	LCE2D	Homo sapiens	Q5TA82	Y2H Array	32296183
Intra	SLC39A7	Q92504	LCE2D	Homo sapiens	Q5TA82	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	SLC39A7	Q92504	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	32296183
Intra	SLC39A7	Q92504	TNFRSF10D	Homo sapiens	Q9UBN6	Validated Y2H	32296183
Intra	SLC39A7	Q92504	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Array	32296183
Intra	SLC39A7	Q92504	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	SLC39A7	Q92504	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	LCE5A	Homo sapiens	Q5TCM9	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	LCE5A	Homo sapiens	Q5TCM9	Y2H Array	32296183
Intra	SLC39A7	Q92504	LCE1F	Homo sapiens	Q5T754	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	LCE1F	Homo sapiens	Q5T754	Y2H Array	32296183
Intra	SLC39A7	Q92504	WFDC12	Homo sapiens	Q8WWY7	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	WFDC12	Homo sapiens	Q8WWY7	Y2H Array	32296183
Intra	SLC39A7	Q92504	LCE1A	Homo sapiens	Q5T7P2	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	LCE2C	Homo sapiens	Q5TA81	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	LCE2C	Homo sapiens	Q5TA81	Y2H Array	32296183
Intra	SLC39A7	Q92504	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	SLC39A7	Q92504	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	RSPO2	Homo sapiens	Q6UXX9-2	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	RSPO2	Homo sapiens	Q6UXX9-2	Y2H Array	32296183
Intra	SLC39A7	Q92504	LCE1C	Homo sapiens	Q5T751	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	LCE1C	Homo sapiens	Q5T751	Y2H Array	32296183
Intra	SLC39A7	Q92504	SPRY3	Homo sapiens	O43610	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	SPRY3	Homo sapiens	O43610	Y2H Array	32296183
Intra	SLC39A7	Q92504	SLC34A2	Homo sapiens	O95436-2	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	SLC34A2	Homo sapiens	O95436-2	Y2H Array	32296183
Intra	SLC39A7	Q92504	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SLC39A7	Q92504	UNC93A	Homo sapiens	Q86WB7-2	Y2H Array	32296183
Intra	SLC39A7	Q92504	UNC93A	Homo sapiens	Q86WB7-2	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	SLC39A7	Q92504	SHISAL1	Homo sapiens	Q3SXP7	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	SHISAL1	Homo sapiens	Q3SXP7	Y2H Array	32296183
Intra	SLC39A7	Q92504	LELP1	Homo sapiens	Q5T871	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	LELP1	Homo sapiens	Q5T871	Y2H Array	32296183
Intra	SLC39A7	Q92504	CSNK2A1	Homo sapiens	P68400	IF	22317921
Intra	SLC39A7	Q92504	CSNK2A1	Homo sapiens	P68400	Anti Bait CoIP	22317921
Intra	SLC39A7	Q92504	RGS17	Homo sapiens	Q9UGC6	Validated Y2H	32296183
Intra	SLC39A7	Q92504	RGS17	Homo sapiens	Q9UGC6	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	RGS17	Homo sapiens	Q9UGC6	Y2H Array	32296183
Intra	SLC39A7	Q92504	KCNF1	Homo sapiens	Q9H3M0	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	KCNF1	Homo sapiens	Q9H3M0	Validated Y2H	32296183
Intra	SLC39A7	Q92504	KCNF1	Homo sapiens	Q9H3M0	Y2H Array	32296183
Intra	SLC39A7	Q92504	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	SLC39A7	Q92504	CRCT1	Homo sapiens	Q9UGL9	Validated Y2H	32296183
Intra	SLC39A7	Q92504	CRCT1	Homo sapiens	Q9UGL9	Y2H Array	32296183
Intra	SLC39A7	Q92504	CRCT1	Homo sapiens	Q9UGL9	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	SMCP	Homo sapiens	P49901	Y2H Prey Pooling	32296183
Intra	SLC39A7	Q92504	SMCP	Homo sapiens	P49901	Y2H Array	32296183
Intra	SLC39A7	Q92504	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	SLC39A7	Q92504	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	SLC39A7	Q92504	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC39A7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810945	ZIP7 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Agammaglobulinemia 9, Autosomal Recessive	AGM9 Agammaglobulinemia, Autosomal Recessive, Due To Slc39a7 Defect
Agammaglobulinemia 9
Acrodermatitis Enteropathica, Zinc-Deficiency Type	Acrodermatitis Enteropathica AEZ Enteropathica Brandt Syndrome Ae Acrodermatitis Enteropathica Zinc Deficiency Type Danbolt-Cross Syndrome Acrodermatitis Enteropathica, Zinc Deficiency Type Inherited Zinc Deficiency Acrodermatitis Enteropathica, Zinc Deficiency Danbolt-Closs Syndrome Primary Zinc Malabsorption Syndrome
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3	Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like Scd-Eds EDSSPD3 Ehlers-Danlos Syndrome Spondylodysplastic Type 3 Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome Slc39a13-Related Speds Slc39a13-Related Spondylodysplastic Eds Spondylocheirodysplastic Ehlers-Danlos Syndrome Speds-Slc39a13 Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Enophthalmos
Ehlers-Danlos Syndrome	Eds Cutis Hyperelastica Elastic Skin Ehlers-Danlos Syndromes Ed Syndrome Ehlers Danlos Syndrome Ehlers Danlos Disease Eds - [Ehlers-Danlos Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114395	NVS-ZP7-4	Inhibitor	98.85%	Unkown
HY-114395A	(R)-NVS-ZP7-4		98.80%	Unkown
HY-RS13238	SLC39A7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC39A7	VGNC	VGNC:46406
Mus musculus	SLC39A7	MGD	MGI:95909
Macaca mulatta	SLC39A7	VGNC	VGNC:77592
Rattus norvegicus	SLC39A7	RGD	RGD:1593280
Bos taurus	SLC39A7	VGNC	VGNC:34867
Others	SLC39A7	NCBI