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  3. NVS-ZP7-4

NVS-ZP7-4 

Cat. No.: HY-114395
Handling Instructions

NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.

For research use only. We do not sell to patients.

NVS-ZP7-4 Chemical Structure

NVS-ZP7-4 Chemical Structure

Size Stock
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

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  • Biological Activity

  • Technical Information

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Description

NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.

IC50 & Target

ZIP7[1].

In Vitro

NVS-ZP7-4 increases ER zinc levels, suggesting functional modulation of ZIP7[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (249.19 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9935 mL 9.9677 mL 19.9354 mL
5 mM 0.3987 mL 1.9935 mL 3.9871 mL
10 mM 0.1994 mL 0.9968 mL 1.9935 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.15 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

501.62

Formula

C₂₈H₂₈FN₅OS

SMILES

O=C(NC12CCN(C[[email protected]@H](NC3=NC4=CC=C(F)C=C4S3)CC5=CC=CC=C5)CC2)NC6=C1C=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

Product Name:
NVS-ZP7-4
Cat. No.:
HY-114395
Quantity:

NVS-ZP7-4

Cat. No.: HY-114395