Granaticin
Granaticin A inhibits the initial stage of RNA biosynthesis, has anti-Gram-positive bacteria, Mycobacterium (weak) and Vaginal trichomonas activity, but also can inhibit tumor cells.
For research use only. We do not sell to patients.
- CAS No.: 19879-06-2
- Formula: C22H20O10
- Molecular Weight:444.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.3 μM
Compound: Granaticin A
|
Cytotoxicity against human A549 cells by MTT assay
Cytotoxicity against human A549 cells by MTT assay
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[PMID: 25153802] |
| HCT-116 | IC50 |
11 μM
Compound: Granaticin A
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Cytotoxicity against human HCT116 cells by MTT assay
Cytotoxicity against human HCT116 cells by MTT assay
|
[PMID: 25153802] |
| HeLa | IC50 |
0.7 μM
Compound: Granaticin A
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Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
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[PMID: 25153802] |
| HepG2 | IC50 |
6.6 μM
Compound: Granaticin A
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Cytotoxicity against human HepG2 cells by MTT assay
Cytotoxicity against human HepG2 cells by MTT assay
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[PMID: 25153802] |
Chemical Information
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CAS No. 19879-06-2
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Molecular Weight 444.39
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Formula C22H20O10
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SMILES
O[C@@]12C3=C(O)C(C(C4=C([C@@]5([H])[C@@](CC(O5)=O)([H])O[C@H]4C)C6=O)=O)=C6C(O)=C3[C@@](O[C@@H]2C)([H])C[C@H]1O
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Synonyms
Granaticin A; Litmomycin
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Structure Classification
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Initial Source
Streptomyces sp. 166
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Granaticin Related Classifications
HY-119968 Related Classifications
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