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Cat. No.: HY-187441

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Insecticidal agent 37

Insecticidal agent 37 is an insecticide with activity against both nymph and adult stages of Aphis fabae. Insecticidal agent 37 exhibits strong binding affinity to the acetylcholine-binding protein of Aplysia californica via forming multiple hydrogen bonds and hydrophobic interactions with key residues.

For research use only. We do not sell to patients.

Formula: C₂₁H₁₂ClN₃OS
Molecular Weight:389.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Insecticidal agent 37 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Insecticidal agent 37 (compound 10b) binds strongly to the Aplysia californica acetylcholine-binding protein (PDB: 3SQ6) with a binding energy of −7.30 kcal/mol, forming multiple stabilizing hydrogen bonds and hydrophobic interactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Insecticidal agent 37 (10b) (five different concentrations; dipping method; single exposure; 10 s) exhibits highly efficient aphicidal activity against nymphs of the broad bean aphid, with an LC₅₀ of 0.117 mg/L^[1].
Insecticidal agent 37 (10b) (five different concentrations; dipping method; single exposure; 10 s) exhibits high aphicidal activity against adult *Aphis fabae*, with an LC₅₀ of 0.366 mg/L^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

nymph stage^[1]
Dosage:

five different concentrations
Administration:

immersion; single exposure; 10 s
Result:

Exhibited a median lethal concentration (LC₅₀) of 0.117 mg/L against Aphis fabae nymphs.

Animal Model:

adult stage^[1]
Dosage:

five different concentrations
Administration:

immersion; single exposure; 10 s
Result:

Exhibited a median lethal concentration (LC₅₀) of 0.366 mg/L against Aphis fabae adults.

Chemical Information

Molecular Weight 389.86
Formula C₂₁H₁₂ClN₃OS
SMILES

N#CC1=C(OC2=C(C1C3=CC=C(C=C3)Cl)SC4=C2C=C5C=CC=CC5=N4)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. A Abdul-Malik M, et al. Design, Synthesis, Characterization, Toxicological Effects, and Molecular Docking Insights of Some Novel Quinoline Compounds as Potential Insecticides. ACS omega. 2026 Jul 28;11(29):44526-44537. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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