Multifungin
Based on 1 publication(s) in Google Scholar
Multifungin (Bromochlorosalicylanilide) is an antifungal that treats oral candidiasis. Multifungin prevents the formation and accumulation of Zearalenone and reduces the fungal population in stored-crushed corn.
For research use only. We do not sell to patients.
- Purity: 99.19%
- CAS No.: 3679-64-9
- Formula: C13H9BrClNO2
- Molecular Weight:326.57
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Multifungin
More
Biological Activity
candidiasis[1]
Multifungin interacts with bacterial cell membranes, changes the intracellular H+ and K+ ion levels, destroys the bacterial proton motive force (PMF), including the transmembrane potential and the transmembrane proton gradient, thereby affecting the respiratory chain function and ATP synthesis, inhibiting phosphatidic acid biosynthesis, and thus exerting antibacterial effect[3].
Multifungin exhibits board-spectrum antibacterial activity, inhibits S. aureus, L. monocytogenes, S. suis, S. epidermidis, S. agalactiae, B. subtilis with MICs of 0.25-1 μg/mL[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Multifungin (10 mg/kg, ip, single dose) exhibits anti-inflammatory activity in mouse peritonitis models[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:G. mellonella-infected mouse models[3]
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Dosage:1.6 mg/kg
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Administration:ip, single dose
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Result:Reduced the bacterial load in the liver and spleen.
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Animal Model:Mouse peritonitis models[3]
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Dosage:10 mg/kg
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Administration:ip, single dose
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Result:Alleviated the lung pathological changes, reduced the infiltration of inflammatory cells, relieved the congestion and edema of the alveolar septa.
Chemical Information
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CAS No. 3679-64-9
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Appearance Solid
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Molecular Weight 326.57
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Formula C13H9BrClNO2
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Color White to off-white
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SMILES
O=C(NC1=CC=C(Cl)C=C1)C2=CC(Br)=CC=C2O
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Synonyms
Bromosalicylchloranilide; Salifungin
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 250 mg/mL (765.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.37 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (284 KB)
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SDS (622 KB)
- English - EN (622 KB)
- Français - FR (622 KB)
- Deutsch - DE (622 KB)
- Norwegian - NO (622 KB)
- Español - ES (622 KB)
- Swedish - SV (622 KB)
- Italian - IT (622 KB)
- Korean - KR (622 KB)
- Portuguese - PT (622 KB)
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Handling Instructions (2659 KB)
References
[1]. Knychalska-Karwan Z, et al. Multifungin in the treatment of oral candidiasis. Czas Stomatol. 1983 Apr;36(4):313-5. [Content Brief]
[3]. Wang C, et al., Discovery of Salifungin as a Repurposed Antibiotic against Methicillin-Resistant Staphylococcus aureus with Limited Resistance Development. ACS Infect Dis. 2024 May 10;10(5):1576-1589. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0621 mL | 15.3107 mL | 30.6213 mL | 76.5533 mL |
| 5 mM | 0.6124 mL | 3.0621 mL | 6.1243 mL | 15.3107 mL | |
| 10 mM | 0.3062 mL | 1.5311 mL | 3.0621 mL | 7.6553 mL | |
| 15 mM | 0.2041 mL | 1.0207 mL | 2.0414 mL | 5.1036 mL | |
| 20 mM | 0.1531 mL | 0.7655 mL | 1.5311 mL | 3.8277 mL | |
| 25 mM | 0.1225 mL | 0.6124 mL | 1.2249 mL | 3.0621 mL | |
| 30 mM | 0.1021 mL | 0.5104 mL | 1.0207 mL | 2.5518 mL | |
| 40 mM | 0.0766 mL | 0.3828 mL | 0.7655 mL | 1.9138 mL | |
| 50 mM | 0.0612 mL | 0.3062 mL | 0.6124 mL | 1.5311 mL | |
| 60 mM | 0.0510 mL | 0.2552 mL | 0.5104 mL | 1.2759 mL | |
| 80 mM | 0.0383 mL | 0.1914 mL | 0.3828 mL | 0.9569 mL | |
| 100 mM | 0.0306 mL | 0.1531 mL | 0.3062 mL | 0.7655 mL |
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