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Cat. No.: HY-144754

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VEGFR-2-IN-13

VEGFR-2-IN-13 (Compound 19a) is a potent VEGFR-2 inhibitor with an IC₅₀ of 3.4 nM. VEGFR-2-IN-13 disrupts the HepG2 cell cycle by arresting the G2/M phase and induces apoptosis.

For research use only. We do not sell to patients.

CAS No.: 2839104-01-5
Formula: C₂₄H₁₈N₆O₂S
Molecular Weight:454.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

VEGFR-2-IN-13 Chemical Structure

CAS No.: 2839104-01-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

VEGFR-2-IN-13 (Compound 19a) is a potent VEGFR-2 inhibitor with an IC₅₀ of 3.4 nM. VEGFR-2-IN-13 disrupts the HepG2 cell cycle by arresting the G2/M phase and induces apoptosis^[1].

IC₅₀ & Target

VEGFR2

3.4 nM (IC₅₀)

All VEGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	IC₅₀	31.34 μM Compound: 19a	Cytotoxicity against rat hepatocytes assessed as reduction in cell growth for 4 hrs by MTT assay Cytotoxicity against rat hepatocytes assessed as reduction in cell growth for 4 hrs by MTT assay	[PMID: 34479065]
HepG2	IC₅₀	5.4 μM Compound: 19a	Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition incubated for 4 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition incubated for 4 hrs by MTT assay	[PMID: 34479065]
MCF7	IC₅₀	8.2 μM Compound: 19a	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 4 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 4 hrs by MTT assay	[PMID: 34479065]

In Vitro

VEGFR-2-IN-13 (Compound 19a) shows anti-proliferative activities with IC₅₀ values of 8.2 µM and 5.4 µM against MCF-7 and HepG2 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2839104-01-5
Molecular Weight 454.50
Formula C₂₄H₁₈N₆O₂S
SMILES

O=C(NC1=CC=C(C=C1)C(NC2=CC=CC=C2)=O)CSC3=NC4=C(N5C=NN=C35)C=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Alsaif NA, et al. Identification of new [1,2,4]triazolo[4,3-a]quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies. Bioorg Med Chem. 2021 Sep 15;46:116384. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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VEGFR-2-IN-13

All VEGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VEGFR-2-IN-13 Related Classifications

HY-144754 Related Classifications