2. Protein Tyrosine Kinase/RTK Apoptosis
  3. VEGFR Apoptosis
  4. VEGFR-2-IN-13

VEGFR-2-IN-13 (Compound 19a) is a potent VEGFR-2 inhibitor with an IC50 of 3.4 nM. VEGFR-2-IN-13 disrupts the HepG2 cell cycle by arresting the G2/M phase and induces apoptosis.

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VEGFR-2-IN-13 Chemical Structure

VEGFR-2-IN-13 Chemical Structure

CAS No. : 2839104-01-5

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VEGFR-2-IN-13 Related Antibodies

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Description

VEGFR-2-IN-13 (Compound 19a) is a potent VEGFR-2 inhibitor with an IC50 of 3.4 nM. VEGFR-2-IN-13 disrupts the HepG2 cell cycle by arresting the G2/M phase and induces apoptosis[1].

IC50 & Target

VEGFR2

3.4 nM (IC50)

In Vitro

VEGFR-2-IN-13 (Compound 19a) shows anti-proliferative activities with IC50 values of 8.2 µM and 5.4 µM against MCF-7 and HepG2 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-13 Related Antibodies
Molecular Weight

454.50

Formula

C24H18N6O2S
CAS No.
SMILES

O=C(NC1=CC=C(C=C1)C(NC2=CC=CC=C2)=O)CSC3=NC4=C(N5C=NN=C35)C=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VEGFR-2-IN-13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-132839104-01-5VEGFRApoptosisVascular endothelial growth factor receptoranticancerHepG2MCF-7BaxBcl-2caspase-3caspase-9low cytotoxicityInhibitorinhibitorinhibit

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