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Cat. No.: HY-147926

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VEGFR-2-IN-28

VEGFR-2-IN-28 (compound 12c) is a potent VEGFR-2 inhibitor with IC₅₀ value of 0.83 µM. VEGFR-2-IN-28 induces apoptosis and has anticancer activity.

For research use only. We do not sell to patients.

CAS No.: 2447597-39-7
Formula: C₂₆H₁₇N₇O₇
Molecular Weight:539.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

VEGFR-2-IN-28 Chemical Structure

CAS No.: 2447597-39-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

VEGFR-2-IN-28 (compound 12c) is a potent VEGFR-2 inhibitor with IC₅₀ value of 0.83 µM. VEGFR-2-IN-28 induces apoptosis and has anticancer activity^[1].

IC₅₀ & Target^[1]

VEGFR-2

0.83 μM (IC₅₀)

All VEGFR Isoforms :

In Vitro

VEGFR-2-IN-28 (compound 12c) (24 hours; MCF-7 cells) has anticancer activity with IC₅₀ value of 16.50 µM^[1].
VEGFR-2-IN-28 (compound 12c) (24 hours; MCF-7 cells) prompts pre-G1 apoptosis, cell growth cessation at G2/M phase and induces apoptosis via activation of caspase-3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

16.50 µM
Incubation Time:

24 hours
Result:

Induced apoptotic cells resulting in apoptosis percentage 28.41 %.

Cell Cycle Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

16.50 µM
Incubation Time:

24 hours
Result:

Increased in the percentage of cells at pre-G1 phase and at G2/M phase to 28.41% and 46.05%, respectively.

Immunofluorescence^[1]

Cell Line:

MCF-7 cells
Concentration:

16.50 µM
Incubation Time:

24 hours
Result:

Increased in the level of caspase-3.

Chemical Information

CAS No. 2447597-39-7
Molecular Weight 539.46
Formula C₂₆H₁₇N₇O₇
SMILES

O=C(N(C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O)N=C/2C)C2=C\C3=CN(C4=CC=CC=C4)N=C3C5=CC=CC([N+]([O-])=O)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dawood DH, et al. Synthesis and molecular docking study of new pyrazole derivatives as potent anti-breast cancer agents targeting VEGFR-2 kinase. Bioorg Chem. 2020 Aug;101:103916. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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VEGFR-2-IN-28

All VEGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VEGFR-2-IN-28 Related Classifications

HY-147926 Related Classifications