1. Cell Cycle/DNA Damage
  2. Checkpoint Kinase (Chk)
  3. VER-00158411

VER-00158411 

Cat. No.: HY-18942
Handling Instructions

VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC50 values of 4.4 nM and 4.5 nM, respectively.

For research use only. We do not sell to patients.

VER-00158411 Chemical Structure

VER-00158411 Chemical Structure

CAS No. : 1174664-88-0

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Description

VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC50 values of 4.4 nM and 4.5 nM, respectively[1].

IC50 & Target[1]

Chk1

4.4 nM (IC50)

Chk2

4.5 nM (IC50)

In Vitro

Cellular sensing of DNA damage, along with concomitant cell cycle arrest, is mediated by a great many proteins and enzymes. One focus of pharmaceutical development has been the inhibition of DNA damage signaling, and checkpoint kinases (CHKs). There have been a number of clinical trial of checkpoint kinase inhibits alone or as a combination therapy for example, as a means to sensitize proliferating tumor cells to chemotherapies that damage DNA. The development of checkpoint kinase inhibitors the treatment of cancer was a major objective in drug discovery[1].

Molecular Weight

538.64

Formula

C₃₁H₃₄N₆O₃

CAS No.

1174664-88-0

SMILES

O=C(C1=CN(CC2=CC=CC=C2)N=C1)NC(C=C3C(N4)=CC5=C4C=CC(OCC(C)(C)CN(C)C)=C5)=CNC3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

VER-00158411VER00158411VER 00158411Checkpoint Kinase (Chk)Inhibitorinhibitorinhibit

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