1. Anti-infection
  2. Virus Protease
  3. Viroxime

Viroxime is an antiviral agent.

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Viroxime

Viroxime Chemical Structure

CAS No. : 63198-97-0

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Description

Viroxime is an antiviral agent[1].

Cellular Effect
Cell Line Type Value Description References
BSC-1 IC50
0.02 μg/mL
Compound: 1
Antiviral activity against Poliovirus (PV-1) using plaque reduction assay using BSC1 cells
Antiviral activity against Poliovirus (PV-1) using plaque reduction assay using BSC1 cells
[PMID: 9341923]
CV-1 ED50
275 μg/mL
Compound: Enviroxime2
Compound was evaluated for chemotherapeutic index in CV-1 cells (chemotherapeutic index=50% cytotoxic dose/50% effective dose)
Compound was evaluated for chemotherapeutic index in CV-1 cells (chemotherapeutic index=50% cytotoxic dose/50% effective dose)
[PMID: 3005577]
CV-1 ED50
8.8 μg/mL
Compound: Enviroxime2
Antiviral activity against poliovirus type 1 in CV-1 cells
Antiviral activity against poliovirus type 1 in CV-1 cells
[PMID: 3005577]
H1-HeLa CC50
9.9 μM
Compound: Enviroxime
Cytotoxicity against human H1-HeLa cells infected with 1 MOI human rhinovirus 14 pretreated with compound for 1 hr followed by viral infection measured by MTT assay
Cytotoxicity against human H1-HeLa cells infected with 1 MOI human rhinovirus 14 pretreated with compound for 1 hr followed by viral infection measured by MTT assay
[PMID: 38389877]
H1-HeLa IC50
41 μM
Compound: Enviroxime
Cytotoxicity against human H1-HeLa cells transfected with EV71 replicon measured after 8 hrs by MTT assay
Cytotoxicity against human H1-HeLa cells transfected with EV71 replicon measured after 8 hrs by MTT assay
[PMID: 38389877]
HeLa ED50
5.1 μg/mL
Compound: Enviroxime2
Antiviral activity against rhinovirus type 10 in Hela cells
Antiviral activity against rhinovirus type 10 in Hela cells
[PMID: 3005577]
HeLa IC50
0.04 μg/mL
Compound: 1
Antiviral activity against Rhinovirus (RV-14) in HeLa cells using CPE/XTT assay
Antiviral activity against Rhinovirus (RV-14) in HeLa cells using CPE/XTT assay
[PMID: 9341923]
HeLa IC50
0.04 μg/mL
Compound: 1
Antiviral activity against Rhinovirus (RV-16) in HeLa cells using CPE/XTT assay
Antiviral activity against Rhinovirus (RV-16) in HeLa cells using CPE/XTT assay
[PMID: 9341923]
HeLa IC50
0.05 μg/mL
Compound: 1
Antiviral activity against Coxsackie virus (CoxA21) in HeLa cells using CPE/XTT assay
Antiviral activity against Coxsackie virus (CoxA21) in HeLa cells using CPE/XTT assay
[PMID: 9341923]
HeLa IC50
0.06 μg/mL
Compound: 1
Antiviral activity against Poliovirus (PV-1) in HeLa cells using CPE/XTT assay
Antiviral activity against Poliovirus (PV-1) in HeLa cells using CPE/XTT assay
[PMID: 9341923]
HeLa IC50
0.07 μg/mL
Compound: 1
Antiviral activity against Rhinovirus (RV-2) in HeLa cells using CPE/XTT assay
Antiviral activity against Rhinovirus (RV-2) in HeLa cells using CPE/XTT assay
[PMID: 9341923]
Huh-7 CC50
25 μM
Compound: 93
Cytotoxicity against human Huh-7 cells
Cytotoxicity against human Huh-7 cells
[PMID: 33539089]
KB CC50
2 μg/mL
Compound: Enviroxime
Cellular toxicity in KB cells
Cellular toxicity in KB cells
[PMID: 12852746]
RD CC50
>223.21 μM
Compound: 1
Cytotoxicity against human RD cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay
Cytotoxicity against human RD cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay
[PMID: 26885567]
RD CC50
1.5 μM
Compound: Enviroxime
Cytotoxicity against human RD cells by neutral red uptake assay
Cytotoxicity against human RD cells by neutral red uptake assay
[PMID: 33031923]
RD CC50
10 μM
Compound: Enviroxime
Cytotoxicity against human RD cells assessed as reduction in cell viability by visual analysis
Cytotoxicity against human RD cells assessed as reduction in cell viability by visual analysis
[PMID: 37120998]
RD CC50
28 μM
Compound: Enviroxime
Cytotoxicity against human RD cells infected with Enterovirus A71 assessed as reduction in cell viability measured by CCK-8 assay
Cytotoxicity against human RD cells infected with Enterovirus A71 assessed as reduction in cell viability measured by CCK-8 assay
[PMID: 32619885]
RD CC50
4.2 μM
Compound: Enviroxime
Cytotoxicity against human RD cells by microscopic based visual inspection method
Cytotoxicity against human RD cells by microscopic based visual inspection method
[PMID: 33031923]
RD CC50
5.5 μM
Compound: Enviroxime
Cytotoxicity against human RD cells assessed as reduction in cell viability by neutral red dye based spectrophotometric analysis
Cytotoxicity against human RD cells assessed as reduction in cell viability by neutral red dye based spectrophotometric analysis
[PMID: 37120998]
RD EC50
0.24 μM
Compound: 1
Antiviral activity against Enterovirus 71 infected in human RD cells after 24 to 36 hrs by MTS-based CPE reduction assay
Antiviral activity against Enterovirus 71 infected in human RD cells after 24 to 36 hrs by MTS-based CPE reduction assay
[PMID: 26885567]
Vero CC50
>100 μM
Compound: 2
Cytotoxicity against African green monkey Vero cells after 3 days by spectrophotometry based MTS/PMS assay
Cytotoxicity against African green monkey Vero cells after 3 days by spectrophotometry based MTS/PMS assay
[PMID: 22305341]
Vero CC50
>100 μM
Compound: 59
Cytotoxicity against african green monkey Vero cells after 3 days by MTS assay
Cytotoxicity against african green monkey Vero cells after 3 days by MTS assay
[PMID: 19924996]
Vero CC50
>223.21 μM
Compound: 1
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay
[PMID: 26885567]
Vero EC50
>186 μM
Compound: 1
Antiviral activity against Human coxsackievirus B4 infected in african green monkey Vero cells by after 24 to 36 hrs MTS-based CPE reduction assay
Antiviral activity against Human coxsackievirus B4 infected in african green monkey Vero cells by after 24 to 36 hrs MTS-based CPE reduction assay
[PMID: 26885567]
Vero EC50
0.026 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 2 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.027 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 41 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 41 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.027 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 63 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 63 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.028 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 39 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 39 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.029 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 29 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 29 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.033 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 85 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 85 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.038 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 9 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 9 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.04 μM
Compound: Enviroxime
Antiviral activity against Human poliovirus 3 strain Sabin infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human poliovirus 3 strain Sabin infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.042 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 15 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 15 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.06 μM
Compound: Enviroxime
Antiviral activity against Human poliovirus 2 Sabin infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human poliovirus 2 Sabin infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.1 μM
Compound: 1
Antiviral activity against Human coxsackievirus B6 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay
Antiviral activity against Human coxsackievirus B6 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay
[PMID: 26885567]
Vero EC50
0.1 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 89 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 89 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.11 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 14 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 14 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.11 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 42 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 42 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.11 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 70 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 70 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.12 μM
Compound: 1
Antiviral activity against Human coxsackievirus B5 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay
Antiviral activity against Human coxsackievirus B5 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay
[PMID: 26885567]
Vero EC50
0.12 μM
Compound: Enviroxime
Antiviral activity against Human coxsackievirus A16 (strain G-10) A16 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human coxsackievirus A16 (strain G-10) A16 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.14 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 86 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 86 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.15 μM
Compound: 1
Antiviral activity against Human coxsackievirus B2 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay
Antiviral activity against Human coxsackievirus B2 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay
[PMID: 26885567]
Vero EC50
0.15 μM
Compound: 1
Antiviral activity against Human enterovirus 71 infected in monkey African green Vero cells by MTS-based CPE reduction assay
Antiviral activity against Human enterovirus 71 infected in monkey African green Vero cells by MTS-based CPE reduction assay
[PMID: 26885567]
Vero EC50
0.15 μM
Compound: Enviroxime
Antiviral activity against Human enterovirus 71 (strain BRCR) infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human enterovirus 71 (strain BRCR) infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.19 μM
Compound: Enviroxime
Antiviral activity against Human poliovirus 1 strain Sabin infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human poliovirus 1 strain Sabin infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.25 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 45 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 45 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.48 μM
Compound: Enviroxime
Antiviral activity against Human coxsackievirus A21 (strain Coe) infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human coxsackievirus A21 (strain Coe) infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.5 μM
Compound: Enviroxime
Antiviral activity against Human coxsackievirus B3 harboring wild type nonstructural protein 3A infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay
Antiviral activity against Human coxsackievirus B3 harboring wild type nonstructural protein 3A infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay
[PMID: 19237651]
Vero EC50
0.7 μM
Compound: 2
Antiviral activity against Coxsackievirus B3 Nancy infected in african green monkey Vero cells assessed as inhibition of virus-induced cell death after 3 days by spectrophotometry based MTS/PMS assay
Antiviral activity against Coxsackievirus B3 Nancy infected in african green monkey Vero cells assessed as inhibition of virus-induced cell death after 3 days by spectrophotometry based MTS/PMS assay
[PMID: 22305341]
Vero EC50
0.7 μM
Compound: 59
Antiviral activity against Coxsackievirus B3 infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect after 3 days by MTS assay
Antiviral activity against Coxsackievirus B3 infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect after 3 days by MTS assay
[PMID: 19924996]
Vero EC50
0.7 μM
Compound: Enviroxime
Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A I8T mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay
Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A I8T mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay
[PMID: 19237651]
Vero EC50
0.72 μM
Compound: Enviroxime
Antiviral activity against Human rhinovirus 72 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Human rhinovirus 72 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
0.75 μM
Compound: 1
Antiviral activity against Human coxsackievirus B1 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay
Antiviral activity against Human coxsackievirus B1 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay
[PMID: 26885567]
Vero EC50
1.3 μM
Compound: 2
Antiviral activity against drug-resistant Coxsackievirus B3 Nancy infected in african green monkey Vero cells assessed as inhibition of virus-induced cell death after 3 days by spectrophotometry based MTS/PMS assay
Antiviral activity against drug-resistant Coxsackievirus B3 Nancy infected in african green monkey Vero cells assessed as inhibition of virus-induced cell death after 3 days by spectrophotometry based MTS/PMS assay
[PMID: 22305341]
Vero EC50
1.5 μM
Compound: Enviroxime
Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A V45A mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay
Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A V45A mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay
[PMID: 19237651]
Vero EC50
1.7 μM
Compound: Enviroxime
Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A H57Y mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay
Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A H57Y mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay
[PMID: 19237651]
Vero EC50
1.8 μM
Compound: Enviroxime
Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A I54F mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay
Antiviral activity against Human coxsackievirus B3 harboring nonstructural protein 3A I54F mutant infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by plaque assay
[PMID: 19237651]
Vero EC50
1.9 μM
Compound: Enviroxime
Antiviral activity against Coxsackievirus B3 (strain Nancy) infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
Antiviral activity against Coxsackievirus B3 (strain Nancy) infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS-based CPE reduction assay
[PMID: 19237651]
Vero EC50
2.48 μM
Compound: 1
Antiviral activity against Human coxsackievirus B3 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay
Antiviral activity against Human coxsackievirus B3 infected in african green monkey Vero cells after 24 to 36 hrs by MTS-based CPE reduction assay
[PMID: 26885567]
Molecular Weight

358.41

Formula

C17H18N4O3S

CAS No.
SMILES

O=S(N1C(N)=NC2=C1C=C(/C(C3=CC=CC=C3)=N/O)C=C2)(C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Viroxime
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