VRX0466617
Based on 1 Customer Validation
VRX0466617 is a selective and ATP-competitive Chk2 inhibitor with an IC50 of 120 nM and a Ki of 11 nM. VRX0466617 does not inhibit the related Chk1 activity. VRX0466617 can be used in the study of cancer.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 926906-64-1
- Formula: C19H20BrN5O2S
- Molecular Weight:462.36
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Chk1 120 nM (IC50) |
Chk1 11 nM (Ki) |
VRX0466617 (10-30 μM) inhibits both the autophosphorylation of Chk2 and the phosphorylation of Cdc25C substrate in vitro kinase reactions[1].
VRX0466617 (0.05-10 μM; 30-180 min) inhibits the phosphorylation of Chk2 Ser19 and Ser33-35, but not of Chk2 Thr68 in ionizing radiation (IR)-induced cells[1].
VRX0466617 induces the phosphorylation of Chk2 Thr68 in the absence of DNA damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LCL-N cells treated with ionizing radiation (IR).
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Concentration:0.05 μM, 0.5 μM, 5 μM, 10 μM
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Incubation Time:30 min, 180 min
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Result:Markedly inhibited the phosphorylation of Ser33-35 and, to a less extent, of Ser19, but not of Thr68.
Chemical Information
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CAS No. 926906-64-1
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Appearance Solid
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Molecular Weight 462.36
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Formula C19H20BrN5O2S
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Color White to off-white
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SMILES
OCC(C)NC(C(C(NS1)=O)=C1NC2=CC=C(NC3=CC=C(Br)C=C3)C=C2)=N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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