WAY-123223
WAY-123223 is an orally active potassium channel (Potassium Channel) blocker. WAY-123223 prolongs the transmembrane action potential duration and cardiac refractory period of canine Purkinje fibers. In canine models, WAY-123223 increases the ventricular fibrillation threshold, restores sinus rhythm from ventricular fibrillation, and exerts antiarrhythmic effects. WAY-123223 can be used in research related to cardiovascular diseases such as arrhythmias.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 137941-92-5
- 分子式: C21H25N3O4S
- 分子量:415.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
WAY-123223 (Compound 12) (0.3-3 μM) dose-dependently prolongs the action potential duration of canine Purkinje fibers; at a concentration of 3 μM (BCL = 300 ms), it increases APD-60mV by 27%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Dog (pentobarbital-anesthetized, open-chest)[1]
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Dosage:5 mg/kg); 10.0 mg/kg (intraduodenal)
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Administration:i.v.; single dose; intraduodenal; single dose
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Result:Increased the ventricular fibrillation threshold from a predrug value of 8.2 mA to 25 mA (a 3-fold increase relative to control).
Restored sinus rhythm spontaneously from ventricular fibrillation without electrical countershock in some cases.
Increased AERP by 45%, increased VERP by 21%, decreased ACT by 9%, decreased VCT by 2%, decreased HR by 18%, and decreased MBP by 9% at 5.0 mg/kg i.v.
(all values are percent change from predrug state).
Increased AERP by 31%, increased VERP by 20%, decreased ACT by 4%, increased VCT by 1%, decreased HR by 15%, and decreased MBP by 5% at 10.0 mg/kg intraduodenal (all values are percent change from predrug state).
化学情報
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CAS 番号 137941-92-5
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分子量 415.51
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分子式 C21H25N3O4S
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SMILES
CS(=O)(NC1=CC=C(OC[C@@H](O)CN(C)CC2=NC3=CC=CC=C3C=C2)C=C1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
WAY-123223 関連分類
HY-119747 関連分類
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