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Cat. No.: HY-158693

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WLB-87848

WLB-87848 is a selective, orally active, and blood-brain barrier (BBB) permeable σ1 receptor agonist with the K_i of 9 nM. WLB-87848 rescues recognition memory impairment.

For research use only. We do not sell to patients.

CAS No.: 2839205-09-1
Formula: C₁₇H₁₅F₂N₃OS
Molecular Weight:347.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

WLB-87848 Chemical Structure

CAS No.: 2839205-09-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

WLB-87848 is a selective, orally active, and blood-brain barrier (BBB) permeable σ1 receptor agonist with the K_i of 9 nM. WLB-87848 rescues recognition memory impairment^[1].

All Sigma Receptor Isoforms :

Chemical Information

CAS No. 2839205-09-1
Molecular Weight 347.38
Formula C₁₇H₁₅F₂N₃OS
SMILES

FC(C=CC([C@H](N1C=NC(SC2=C3CCNC2)=C3C1=O)C)=C4)=C4F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Christmann U, et al. WLB-87848, a Selective σ1 Receptor Agonist, with an Unusually Positioned NH Group as Positive Ionizable Moiety and Showing Neuroprotective Activity. J Med Chem. 2024;67(11):9150-9164. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
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WLB-87848

All Sigma Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

WLB-87848 Related Classifications

HY-158693 Related Classifications