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Cat. No.: HY-190852

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YAP-TEAD-IN-4

YAP-TEAD-IN-4 is a YAP-TEAD protein-protein interaction inhibitor. YAP-TEAD-IN-4 inhibits YAP-TEAD protein-protein interaction and suppresses TEAD-dependent transcriptional activity, with an IC₅₀ of 1.19 μM. YAP-TEAD-IN-4 reduces lung tumor burden and lung colonization in the B16-F10 melanoma lung colonization mouse model. YAP-TEAD-IN-4 can be used for melanoma-related research.

For research use only. We do not sell to patients.

CAS No.: 3122151-07-6
Formula: C₂₁H₂₂N₂O₄S₂
Molecular Weight:430.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (287 KB)

YAP-TEAD-IN-4 Chemical Structure

CAS No.: 3122151-07-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

YAP/TAZ-TEAD

TEAD

All YAP Isoforms :

In Vitro

YAP-TEAD-IN-4 (compound 9d) (20 μM) inhibits YAP-TEAD PPI in GP2-293 cells by more than 70% within 24 h^[1].
YAP-TEAD-IN-4 inhibits YAP-TEAD-dependent transcriptional activity in GP2-293 cells with an IC₅₀ of 1.19 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancer

YAP-TEAD-IN-4 (compound 9d) (5-10 mg/kg; i.v.; every three days; 14 days) reduces pulmonary melanoma colonization in a dose-dependent manner in B16-F10-injected C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (8 × 10⁵ cells/100 μL B16-F10 cells)^[1]
Dosage:

5 mg/kg; 10 mg/kg
Administration:

i.v.; every three days; 14 days
Result:

Reduced pulmonary surface lung nodules to 50 per lung at 5 mg/kg, corresponding to a 73.9% reduction relative to vehicle.
Reduced pulmonary surface lung nodules to 38 per lung at 10 mg/kg, corresponding to an 80.2% reduction relative to vehicle.

Related Protocols :

Chemical Information

CAS No. 3122151-07-6
Molecular Weight 430.54
Formula C₂₁H₂₂N₂O₄S₂
SMILES

CC(C=C1)=CC2=C1N3C4=C2CCCC4N(S(C5=C(C(OC)=O)SC=C5)(=O)=O)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (287 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fei X, et al. Tetracyclic pyrazinocarbazole derivatives as YAP-TEAD pathway inhibitors with activity in a melanoma lung colonization model. Bioorganic chemistry. 2026 Sep 27;183:110592. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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