2. Cell Cycle/DNA Damage Apoptosis
  3. DNA/RNA Synthesis Apoptosis
  4. Zn(BQTC)

Zn(BQTC) is a highly potent mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) inhibitor. Zn(BQTC) causes severe damage to the mtDNA and nDNA, sequentially disruptes mitochondrial and nuclear functions. Zn(BQTC) promotes the DNA damage-induced apoptotic signaling pathway. Zn(BQTC) has selectively antiproliferative activity against A549R cells. Zn(BQTC) can be used for researching anticancer.

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Zn(BQTC) Chemical Structure

Zn(BQTC) Chemical Structure

CAS No. : 2785342-54-1

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Zn(BQTC) Related Antibodies

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Description

Zn(BQTC) is a highly potent mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) inhibitor. Zn(BQTC) causes severe damage to the mtDNA and nDNA, sequentially disruptes mitochondrial and nuclear functions. Zn(BQTC) promotes the DNA damage-induced apoptotic signaling pathway. Zn(BQTC) has selectively antiproliferative activity against A549R cells. Zn(BQTC) can be used for researching anticancer[1].

IC50 & Target

IC50: 10 nM in A549R cells[1]
In Vitro

Zn(BQTC) (0-100 μM; 6 hours) exhibits highly and selectively antiproliferative activity against A549R with an IC50 of 10 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zn(BQTC) Related Antibodies

Cell Proliferation Assay

Cell Line: A549R, A549 and HL-7702[1]
Concentration: 0-100 μM
Incubation Time: 6 hours
Result: Exhibited potent antiproliferative activity against A549R and A549 cells with IC50s of 10 nM and 11.59 μM, but low activity against HL-7702 with an IC50 over 100 μM.
Molecular Weight

650.92

Formula

C30H36Cl2N5O3Zn
CAS No.
SMILES

O=C([N]12[Zn+2]34N(CCN3CCN4CC2)CC1)CCCCCCOC5=C6C(C7=C(O6)C=CC=C7)=NC8=CC=CC=C58.[Cl-].[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Zn(BQTC) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zn(BQTC)2785342-54-1DNA/RNA SynthesisApoptosisAnticancerA549RMitochondrial functionNuclear functionInhibitorinhibitorinhibit

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