Zn(BQTC)
Zn(BQTC) is a highly potent mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) inhibitor. Zn(BQTC) causes severe damage to the mtDNA and nDNA, sequentially disruptes mitochondrial and nuclear functions. Zn(BQTC) promotes the DNA damage-induced apoptotic signaling pathway. Zn(BQTC) has selectively antiproliferative activity against A549R cells. Zn(BQTC) can be used for researching anticancer.
For research use only. We do not sell to patients.
- CAS No.: 2785342-54-1
- Formula: C30H39Cl2N5O3Zn
- Molecular Weight:653.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All DNA/RNA Synthesis Isoforms
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Biological Activity
IC50: 10 nM in A549R cells[1]
Zn(BQTC) (0-100 μM; 6 hours) exhibits highly and selectively antiproliferative activity against A549R with an IC50 of 10 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549R, A549 and HL-7702[1]
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Concentration:0-100 μM
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Incubation Time:6 hours
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Result:Exhibited potent antiproliferative activity against A549R and A549 cells with IC50s of 10 nM and 11.59 μM, but low activity against HL-7702 with an IC50 over 100 μM.
Chemical Information
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CAS No. 2785342-54-1
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Molecular Weight 653.95
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Formula C30H39Cl2N5O3Zn
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SMILES
O=C([N]12[Zn+2]([NH]3CC2)([NH]4CC3)[NH](CC4)CC1)CCCCCCOC5=C(OC6=CC=CC=C76)C7=NC8=CC=CC=C58.[Cl-].[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)