Zopiclone N-oxide
Zopiclone N-oxide (RP 29753) is a less active metabolite of Zopiclone. Zopiclone N-oxide is also an impurity of Eszopiclone and is formed by the oxidation of Eszopiclone.
For research use only. We do not sell to patients.
- CAS No.: 43200-96-0
- Formula: C17H17ClN6O4
- Molecular Weight:404.81
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 43200-96-0
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Appearance Solid
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Molecular Weight 404.81
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Formula C17H17ClN6O4
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Color Off-white to light yellow
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SMILES
O=C(N1CC[N+](C)([O-])CC1)OC2N(C3=NC=C(Cl)C=C3)C(C4=NC=CN=C42)=O
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Synonyms
RP 29753
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 16.67 mg/mL (41.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Portuguese - PT (761 KB)
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Handling Instructions (2659 KB)
References
[1]. C Fernandez, et al. Pharmacokinetics of zopiclone and its enantiomers in Caucasian young healthy volunteers. Drug Metab Dispos. Nov-Dec 1993;21(6):1125-8. [Content Brief]
[2]. Yu Sha, et al. Synthesis of RP 48497, an impurity of eszopiclone. Molecules. 2008 Aug 22;13(8):1817-21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4703 mL | 12.3515 mL | 24.7029 mL | 61.7574 mL |
| 5 mM | 0.4941 mL | 2.4703 mL | 4.9406 mL | 12.3515 mL | |
| 10 mM | 0.2470 mL | 1.2351 mL | 2.4703 mL | 6.1757 mL | |
| 15 mM | 0.1647 mL | 0.8234 mL | 1.6469 mL | 4.1172 mL | |
| 20 mM | 0.1235 mL | 0.6176 mL | 1.2351 mL | 3.0879 mL | |
| 25 mM | 0.0988 mL | 0.4941 mL | 0.9881 mL | 2.4703 mL | |
| 30 mM | 0.0823 mL | 0.4117 mL | 0.8234 mL | 2.0586 mL | |
| 40 mM | 0.0618 mL | 0.3088 mL | 0.6176 mL | 1.5439 mL |
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