β2AR antagonist 1
β2AR antagonist 1 is a potent β2-adrenergic receptor (β2AR) inhibitor. β2AR antagonist 1 exhibits high selectivity for β2AR over β1AR, vasopressin receptor type 2, and angiotensin type 1 receptor. β2AR antagonist 1 stabilizes the inactive conformation of β2AR and interferes with its coupling to G proteins and β-arrestins.
For research use only. We do not sell to patients.
- CAS No.: 2135743-21-2
- Formula: C41H51BrN4O9
- Molecular Weight:823.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
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Beta-2 adrenergic receptor |
β2AR antagonist 1 (Cmpd-15PA) (90 min) reduces orthosteric agonist isoproterenol binding affinity for wild-type β2AR and β2AR-T4L[1].
β2AR antagonist 1 (10 nM-100 μM; 90 min) inhibits high-affinity orthosteric agonist binding to phosphorylated β2V2R in the presence of GS (IC50 = 2.3 μM) and β-arrestin1 (IC50 = 2.2 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2135743-21-2
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Molecular Weight 823.77
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Formula C41H51BrN4O9
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SMILES
NC(C(C=C1)=CC=C1C[C@@H](C(N[C@H](C(NCCOCCOCCOCC(O)=O)=O)CC2=CC(Br)=CC=C2)=O)NC(C(C3=CC=CC=C3)C4CCCCC4)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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